Prognostic significance of CD83 positive tumor-infiltrating dendritic cells and expression of TGF-beta 1 in human gastric cancer.

Background/aims: In this study we analyzed the significance of CD1a and CD83 positive tumor infiltrating dendritic cells (TIDCs) and the expression of TGF-β1 in gastric cancer tissue, and their relationship with disease progression and prognosis of patients.

Methodology: The immunohistochemical expression of CD1a, CD83 and TGF-β1, was evaluated in 55 patients with gastric cancer and followed-up for five years.

Results: We found tumor infiltration with CD1a and CD83 positive DCs in all 55 cases and cytoplasmic TGF-β1 immunoreactivity in tumor cells in 76.