Publications by authors named "Irem Okcular"

Aims: Assessment of microvascular function after reperfused acute myocardial infarction (AMI) provides important insights for myocardial reperfusion and facilitates prediction of long-term left ventricular (LV) function and clinical outcome. In this study, we examined microvascular integrity 48 h after successful primary percutaneous coronary intervention (PCI) and compared predictive accuracy of the intracoronary pressure-wire- and transthoracic Doppler echocardiography-based parameters in the estimation of long-term LV infarct size and function.

Methods And Results: The study group consisted of 30 anterior AMI patients who were treated successfully with primary PCI.

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Unlabelled: Despite its prognostic importance, accurate assessment of microvascular perfusion in patients with ST elevation acute myocardial infarction (STEMI) is difficult. As a new tool, the index of microvascular resistance (IMR) measurement provides us a new opportunity for interrogating microvascular condition after STEMI. In this study, we measured IMR in infarct-related artery (IRA) and explored its relation with other indices which have been suggested to evaluate microvascular perfusion in patients with reperfused STEMI.

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Article Synopsis
  • The study aimed to assess whether administering low-dose intracoronary streptokinase after primary PCI could improve microvascular perfusion, which is often impaired following the procedure.
  • Two days post-PCI, patients receiving streptokinase showed significantly better microvascular function compared to the control group in several hemodynamic measures.
  • Despite the initial improvements in microvascular function, there were no significant differences in left ventricular size or function observed between the two groups after six months.
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Background: In acute myocardial infarction (AMI), increased neutrophil count has been associated with more severe coronary artery disease and larger infarct size. Increased mean platelet volume (MPV) is also associated with poor clinical outcome and impaired angiographic reperfusion in patients with AMI. However, the associations of neutrophil count and MPV with the indices of tissue level reperfusion were not fully elucidated.

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The potential of individuals to develop coronary collateral circulation is often neglected but is of potential major importance in myocardial vulnerability. Likewise, the effect of chronic kidney disease (CKD) on collateral vessel development is not known. The purpose of this study was to evaluate the effect of CKD on collateral development in patients with advanced coronary artery disease.

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Article Synopsis
  • The study explores how the pressure-derived collateral flow index can predict long-term changes in left ventricular remodeling after acute myocardial infarction.
  • It involved 28 patients who underwent stent implantation post-myocardial infarction, with microvascular dysfunction quantitatively assessed using intracoronary pressure wire.
  • Results showed a strong correlation between the collateral flow index and both left ventricular volume and its changes over one year, making it a significant predictor for cardiac remodeling.
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