Cushing's disease (CD) co-occurring with chronic kidney disease (CKD) is rare and makes diagnosis challenging due to CKD-induced hypercortisolism; this report presents three female cases to improve understanding of diagnosis in such contexts.
Each patient, aged between 12 and 16, had various CKD-related conditions and presented symptoms typical of CD, which were confirmed through clinical and biochemical evaluations; surgical interventions led to remission, but some patients developed pituitary deficiencies.
These cases highlight the need for careful clinical assessment in diagnosing CD among CKD patients, as clear diagnostic criteria are currently lacking.