Publications by authors named "Irani Rudiman"

Article Synopsis
  • Dengue has become a major infectious disease over the past 50 years, with increasing outbreaks and serious symptoms like fever, rash, and bleeding affecting both children and adults, highlighting the need for targeted public health strategies.
  • A study in West Java, Indonesia, involving 4,380 adults from 2000-2009 found that dengue infections were confirmed in 12.4% of documented febrile episodes, revealing a yearly incidence rate of 17.3 cases per 1,000 person-years, with asymptomatic cases being more common than symptomatic ones.
  • The findings show that dengue virus accounted for a significant portion of febrile illnesses in the region, with the study's incidence rate being substantially higher than official
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Dengue viruses (DV), composed of four distinct serotypes (DV1 to DV4), cause 50 to 100 million infections annually. Durable homotypic immunity follows infection but may predispose to severe subsequent heterotypic infections, a risk conferred in part by the immune response itself. Antibody-dependent enhancement (ADE), a process best described in vitro, is epidemiologically linked to complicated DV infections, especially in Southeast Asia.

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In 1992, the Indonesian CDC implemented strategies to control and prevent dengue fever (DF) by including community involvement to reduce larva breeding sites and a mass health education program. To contribute to this effort, we incorporated an educational component into a prospective study of DF conducted at two textile factories in Bandung. This education provided: a lecture on the signs and symptoms of dengue and ways to prevent the disease, posters in the health clinic at each factory and handouts given to each volunteer with an explanation of symptoms.

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