Publications by authors named "Iraj Jafari Anarkoli"
Stroke is the most common reason for adult disabilities and the second ground for death worldwide. Our previous study revealed that selegiline serves as an alternative candidate in transient hypoxia-ischemia. However, aggressive and restless behavior was observed in stroke-induced rats receiving 4 mg/kg selegiline.
View Article and Find Full Text PDFSelegiline (L-deprenyl) is the major drug which is used in the treatment of Parkinson's disease because of its neurotrophic and antiapoptotic properties. Previous studies suggested that low dose of L-methamphetamine (L-METH) caused lower mortality rate in patients with severe traumatic brain injury. As L-methamphetamine is one of the metabolites of selegiline, the present study aims to examine whether L-deprenyl can improve cognitive, biochemical, and histopathological injury in animal model of transient global ischemia.
View Article and Find Full Text PDFArticle Synopsis
- Cognitive dysfunction is a common issue in patients with diabetes, and a study was conducted to see if aminoguanidine (AG) could improve cognitive function and gene expression related to memory.
- Researchers divided rats into different groups, including diabetics and controls, and assessed their memory using a passive avoidance learning test after administering AG.
- The results showed that AG improved cognitive performance in diabetic rats and influenced the expression of important genes involved in cell death and survival, suggesting a potential therapeutic effect in managing cognitive dysfunction related to diabetes.