Publications by authors named "Iracema Gomes Araujo"
Angiotensin II (Ang II) acts on Ang II type 1 (AT1) receptors located in the organum vasculosum and subfornical organ (SFO) of the lamina terminalis as a main facilitatory mechanism of sodium appetite. The brain serotonin (5-HT) system with soma located in the dorsal raphe nucleus (DRN) provides a main inhibitory mechanism. In the present study, we first investigated the existence of Ang II AT1 receptors in serotonergic DRN neurones.
View Article and Find Full Text PDFFemale Wistar rats were ovariectomized (OVX) and separated into two groups that received either estradiol cypionate (EC, 40 μg/kg, sc; OVX-EC) or vehicle (corn oil, sc; OVX-oil) for 14 consecutive days. On the 7th day of treatment, a subset of animals from both the OVX-oil and OVX-EC groups was subjected to subchronic losartan (AT1 receptor antagonist) treatment (0.1g/L in drinking water; ~15 mg/kg/day) for 7 days.
View Article and Find Full Text PDFArticle Synopsis
- The study explored how 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus (DRN) influence salt intake in rats, particularly during sodium depletion.
- Acute administration of 8-OH-DPAT, a 5-HT(1A) agonist, led to increased salt intake, indicating its role in promoting salt preference.
- Chronic treatment with 8-OH-DPAT, however, reduced salt intake over time in sodium-depleted rats, suggesting these autoreceptors play a significant role in regulating both immediate and long-term responses to sodium levels.