Publications by authors named "Ira Zubkoff"
J Neurophysiol
February 2007
Article Synopsis
- The A118G SNP in the human mu-opioid receptor gene leads to a change in amino acids that affects how opioids interact with the receptor.
- The study compares the effects of different opioid agonists on both the wild-type and mutant forms of the mu-opioid receptor in rat neurons, using advanced techniques to measure their potency.
- Findings indicate that the mutant hMOR variant shows a different signaling pathway, which could explain why individuals with this genetic variant have varied responses to opioid medications.
