Publications by authors named "Ira J Kallio-Kujala"
Objective: To investigate effects of vatinoxan in dogs, when administered as intravenous (IV) premedication with medetomidine and butorphanol before anaesthesia for surgical castration.
Study Design: A randomized, controlled, blinded, clinical trial.
Animals: A total of 28 client-owned dogs.
Concentrations of medetomidine enantiomers and vatinoxan, an α-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs.
Vet Anaesth Analg
January 2020
Objective: To quantify the peripheral selectivity of vatinoxan (L-659,066, MK-467) in dogs by comparing the concentrations of vatinoxan, dexmedetomidine and levomedetomidine in plasma and central nervous system (CNS) tissue after intravenous (IV) coadministration of vatinoxan and medetomidine.
Study Design: Experimental, observational study.
Animals: A group of six healthy, purpose-bred Beagle dogs (four females and two males) aged 6.
Objective: To investigate the cardiovascular and sedation reversal effects of IM administration of atipamezole (AA) in dogs treated with medetomidine hydrochloride (MED) or MED and vatinoxan (MK-467).
Animals: 8 purpose-bred, 2-year-old Beagles.
Procedures: A randomized, blinded, crossover study was performed in which each dog received 2 IM treatments at a ≥ 2-week interval as follows: injection of MED (20 μg/kg) or MED mixed with 400 μg of vatinoxan/kg (MEDVAT) 30 minutes before AA (100 μg/kg).
Objective: We determined the possible effects of a peripherally acting α-adrenoceptor antagonist, MK-467, on the absorption of intramuscularly (IM) coadministered medetomidine, butorphanol and midazolam.
Study Design: Randomized, experimental, blinded crossover study.
Animals: Six healthy Beagle dogs.