Green tea extract catechin improves cardiac function in pediatric cardiomyopathy patients with diastolic dysfunction.

Background: Our previous studies have demonstrated that Ca desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effects of green tea extract catechin on cardiac function and other clinical features in pediatric patients with cardiomyopathies.

Methods: Twelve pediatric cardiomyopathy patients with diastolic dysfunction were enrolled for the study.

Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations.

Our aim was to explore the dose-dependent diastolic dysfunction and the mechanisms of heart failure and early death in transgenic (TG) mice modeling human restrictive cardiomyopathy (RCM). The first RCM mouse model (cTnI(193His) mice) carrying cardiac troponin I (cTnI) R193H mutation (mouse cTnI R193H equals to human cTnI R192H) was generated several years ago in our laboratory. The RCM mice manifested a phenotype similar to that observed in RCM patients carrying the same cTnI mutation, i.