Long-lived enhanced magnetization-A practical metabolic MRI contrast material.

Noninvasive tracking of biochemical processes in the body is paramount in diagnostic medicine. Among the leading techniques is spectroscopic magnetic resonance imaging (MRI), which tracks metabolites with an amplified (hyperpolarized) magnetization signal injected into the subject just before scanning. Traditionally, the brief enhanced magnetization period of these agents limited clinical imaging.

Resilient Intracrystalline Occlusions: A Solid-State NMR View of Local Structure as It Tunes Bulk Lattice Properties.

In many marine organisms, biomineralization-the crystallization of calcium-based ionic lattices-demonstrates how regulated processes optimize for diverse functions, often via incorporation of agents from the precipitation medium. We study a model system consisting of l-aspartic acid (Asp) which when added to the precipitation solution of calcium carbonate crystallizes the thermodynamically disfavored polymorph vaterite. Though vaterite is at best only kinetically stable, that stability is tunable, as vaterite grown with Asp at high concentration is both thermally and temporally stable, while vaterite grown at 10-fold lower Asp concentration, yet 2-fold less in the crystal, spontaneously transforms to calcite.

The shell matrix and microstructure of the Ram's Horn squid: Molecular and structural characterization.

Molluscs are one of the most diversified phyla among metazoans. Most of them produce an external calcified shell, resulting from the secretory activity of a specialized epithelium of the calcifying mantle. This biomineralization process is controlled by a set of extracellular macromolecules, the organic matrix.

Biomacromolecules within bivalve shells: Is chitin abundant?

Bivalve shells are inorganic-organic nanocomposites whose material properties outperform their purely inorganic mineral counterparts. Most typically the inorganic phase is a polymorph of CaCO, while the organic phase contains biopolymers which have been presumed to be chitin and/or proteins. Identifying the biopolymer phase is therefore a crucial step in improving our understanding of design principles relevant to biominerals.

Molecular level characterization of the inorganic-bioorganic interface by solid state NMR: alanine on a silica surface, a case study.

The molecular interface between bioorganics and inorganics plays a key role in diverse scientific and technological research areas including nanoelectronics, biomimetics, biomineralization, and medical applications such as drug delivery systems and implant coatings. However, the physical/chemical basis of recognition of inorganic surfaces by biomolecules remains unclear. The molecular level elucidation of specific interfacial interactions and the structural and dynamical state of the surface bound molecules is of prime scientific importance.

In situ observation of the internal structure and composition of biomineralized Emiliania huxleyi calcite by solid-state NMR Spectroscopy.

Biomineralization, particularly the formation of calcium carbonate structures by organisms under ambient conditions, is of vast fundamental and applied interest. Organisms finely control all aspects of the formation of the biomaterials: composition, polymorph, morphology, and macroscopic properties. While in situ molecular-level characterization of the resulting biominerals is a formidable task, solid-state magic angle spinning NMR is one of the most powerful analytical techniques for this purpose.