Publications by authors named "Ipsita Mukherjee"

Human Immunodeficiency Virus (HIV) remains a global health challenge, and novel approaches to improve HIV control are significantly important. The cell and gene therapy product AGT103-T was previously evaluated (NCT04561258) for safety, immunogenicity, and persistence in seven patients for up to 180 days post infusion. In this study, we sought to investigate the impact of AGT103-T treatment upon analytical treatment interruptions (ATIs).

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is the leading cause of skin and soft tissue infections (SSTIs) in the U.S. as well as more serious invasive diseases, including bacteremia, sepsis, endocarditis, surgical site infections, osteomyelitis, and pneumonia.

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Background: Cigarette smoking remains a primary cause of chronic lung diseases. After a steady decline, smoking rates have recently increased especially with the introduction of newer electronic nicotine delivery devices, and it is also emerging that dual- or poly-product usage is on the rise. Additionally, with the introduction of IQOS (a heated tobacco product) globally, its impact on human health needs to be investigated.

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Article Synopsis
  • Superbugs like MRSA and VRSA are becoming increasingly resistant to treatment, causing severe infections and posing a major health challenge as there are no FDA-approved vaccines to combat them.
  • Recent research focused on developing a vaccine (IBT-V02) that elicited strong immune responses in rabbits against key toxins, showing promising results for future anti-virulence therapies.
  • The study demonstrated that both full-length IgG and F(ab') antibody products effectively neutralized multiple toxins and provided protection in models of serious infections, indicating potential for these products in treating life-threatening bacterial infections.
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causes a wide range of diseases from skin infections to life threatening invasive diseases such as bacteremia, endocarditis, pneumonia, surgical site infections, and osteomyelitis. Skin infections such as furuncles, carbuncles, folliculitis, erysipelas, and cellulitis constitute a large majority of infections caused by (SA). These infections cause significant morbidity, healthcare costs, and represent a breeding ground for antimicrobial resistance.

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(SA) infections cause high mortality and morbidity in humans. Being central to its pathogenesis, thwarts the host defense by secreting a myriad of virulence factors, including bicomponent, pore-forming leukotoxins. While all vaccine development efforts that aimed at achieving opsonophagocytic killing have failed, targeting virulence by toxoid vaccines represents a novel approach to preventing mortality and morbidity that are caused by SA.

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Article Synopsis
  • Cytolytic pore-forming toxins like alpha hemolysin (Hla) and leukotoxins are crucial for the pathogenicity of certain bacteria, killing immune cells and providing nutrients for growth.
  • A mutation in the SaeS sensor enhances a strain's toxin activity independently from Hla, allowing it to lyse human red blood cells more effectively.
  • Research shows that this Hla-independent activity relies on the gamma hemolysin A subunit and emphasizes the role of Sae and Agr systems in bacterial virulence, which is important for developing vaccines and treatments.
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B lymphocyte stimulator (BLyS) is a member of the TNF superfamily of cytokines. The biological activity of BLyS is mediated by three cell surface receptors: BR3/BAFF-R, TACI and BCMA. The expression of these receptors is highly restricted to B cells, both normal and malignant.

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The La protein is a target of autoantibodies in patients suffering from Sjögren's syndrome, systemic lupus erythematosus, and neonatal lupus. Ubiquitous in eukaryotes, La functions as a RNA-binding protein that promotes the maturation of tRNA precursors and other nascent transcripts synthesized by RNA polymerase III as well as other noncoding RNAs. La also associates with a class of mRNAs that encode ribosome subunits and precursors to snoRNAs involved in ribosome biogenesis.

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