Orthopantomography and INAIL assessment of dental injury. Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro.

The protection of workers' health is defended by the Italian Constitution, and sees its most extensive application in the work of the INAIL (Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro-National Institute for Assurance against Work-related Accidents). In the T.U.

Orthopantomography and the determination of majority age.

The problem of determining a subject's age to ascertain whether he can be criminally charged brings to prominence all the methods of investigation which can be used to define a person's biological age. The methodologies used to determine dental age still represent today the most sensitive means of arriving at this end. Researchers in Turin in 1980 elaborated an equational formula to determine a subject's presumable age by means of orthopantomography, basing the examination on the mineralization times of 4.

Opioid and non-opioid effects of novel butyrophenone analogues.

Haloperidol, haloperidol propionate, and a haloperidol analogue N-3-(p-fluorobenzoyl) propyl-4-phenyl-4-propionyl-oxypiperidine (NIH 10495) were evaluated in several in vitro and in vivo tests of opioid effects. Haloperidol bound to opioid receptors with very low affinity and had no opioid agonist effects in the other test systems. Haloperidol propionate was 10 times less potent than NIH 10495 in the binding assay and in the smooth-muscle assay.

The perilymphatic hypertension syndrome.

Perilymphatic hypertension is usually related to gushers which occur in the operating room when the stapes footplate is punctured or removed. These patients present defects in the modiolus, or enlarged cochlear aqueducts, which allow easy access of spinal fluid to the perilymphatic space. This syndrome was detected in children and appears to present consistent audiological patterns.

Synthesis, stereochemistry, and biological activity of the 1-(1-phenyl-2-methylcyclohexyl)piperidines and the 1-(1-phenyl-4-methylcyclohexyl)piperidines. Absolute configuration of the potent trans-(-)-1-(1-phenyl-2-methylcyclohexyl)piperidine.

The (-)- and (+)-isomers of the cis- and trans-Ph/Me 1-(1-phenyl-2-methylcyclohexyl)piperidines have been synthesized and the achiral cis- and trans-Ph/Me 1-(1-phenyl-4-methylcyclohexyl)piperidines were prepared, and their in vitro [displacement of [3H]TCP (1-[1-(2-thienylcyclohexyl)]piperidine) from the PCP (1-(1-phenylcyclohexyl)piperidine) binding site] and in vivo (rotarod assay) activities determined. The 1-(1-phenyl-2-methylcyclohexyl)piperidine isomers were resolved by classical crystallization procedures, through the diastereomeric salts obtained with d- and l-10-camphorsulfonic acid. The relative stereochemistry of the cis- and trans-Ph/Me 1-(1-phenyl-2-methylcyclohexyl)piperidines and the achiral cis- and trans-Ph/Me 1-(1-phenyl-4-methylcyclohexyl)piperidines was established by using 13C and 1H NMR.

Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds.

The two optical isomers of 1-[3-(p-fluorobenzoyl) propyl]-3-methyl-4-phenyl-4-propionoxypiperidine (FPP) were obtained by resolution of (+/-)-r-3-methyl-4-phenyl-c-4-piperidinol followed by N-alkylation and O-propionylation. These, as well as the racemate, were evaluated for their antinociceptive, opioid, and neuroleptic properties using in vivo and in vitro test systems. The results are remarkable in two respects, namely, the dextrorotatory isomer is consistently the most potent on all tests, and it acts on both opioid (mu) and neuroleptic (D2) receptors.

In vivo effect of eflornithine (DFMO) and some related compounds on Leishmania infantum preliminary communication.

An in vivo method was used to test the effect of eflornithine (DFMO) and five related compounds on Leishmania infantum amastigotes. Treatment with 100 mg/kg sc for 5 days of Leishmania infected Balb/c mice yielded a parasite inhibition ranging from 56% (compound 2, "reverse arginine") to 85% (eflornithine), these values being lower than that obtained with the reference compound Glucantime (93%). In long-term treatment (40 days) the two selected compounds, eflornithine and 3 ("reverse homoarginine"), failed to cure the animals.

[Aluminum lung as an occupational disease. Case reports].

The cases are examined of 13 males, mean age 53, granted disability pensions by the Turin I.N.A.

[Talcosis as an occupational disease. Case histories].

The case are examined of 49 people (45 males, 4 females), mean age 60 exposed to the risk of talc inhalation in a talc processing and packing factory who were granted disability pensions by the Turin I.N.A.

Water buffalo (Bubalus bubalis) hemoglobins: an electrophoretic and chromatographic study.

1. Hemoglobins from three phenotypes of Italian water buffalo (Bubalus bubalis), named AA, AB and BB, were selected by starch gel electrophoresis at alkaline pH and analyzed using polyacrylamide gel isoelectric focusing and subsequent analysis of titration curves to reveal differences between two types of hemoglobin identified as Hb fast and Hb slow. 2.

[The problem of informed consent in dental treatment of the handicapped].

The juridical and medical aspects of disability and the treatment of the disabled permitted by law are described with particular reference to the borderline situations most often encountered in dentistry, in order to highlight the fact that the implicit or explicit consent of the patient's legal representative must always be obtained.

Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.

Some 4-phenyl-4-piperidinols, corresponding esters, and related compounds with a p-fluorobutyrophenone chain on nitrogen were synthesized and evaluated in in vitro and in vivo tests in order to examine their ability to interact contemporaneously with opioid and dopamine receptors. The propionyloxy derivatives showed a good combination of analgesic and neuroleptic activity. With a 3-methyl substituent on the piperidine ring, the beta-configuration was the more active form not only for analgesic activity, as expected from previous results on prodines, but also for neuroleptic activity.

Quantitative analysis of beta-adrenergic blocking agents by NMR spectroscopy.

The quantitative analysis by (1)H NMR of labetalol, oxprenolol and four other beta-adrenergic blocking agents is described. The method depends on the integration of selected resonances of the analyte and an internal reference which do not overlap. Procedures for the extraction of the analyte from tablets are given and corrections due to the NMR features of excipients outlined in some cases.

[Occupational asthma from the use of synthetic resins. Personal case histories and a review of the literature].

33 cases of occupational asthma in plastics workers encountered by Turin INAIL in 1971-85 are examined. Functional and immunological test data reveal the possibility of various asthmogenic mechanisms both immune and non-immune.