Publications by authors named "Iori Kanazawa"
Article Synopsis
- A new technology was developed to extend the lifespan and maintain the differentiation ability of human mesenchymal stem cells (hMSCs) using nonintegrative, temperature-sensitive Sendai virus vectors.
- This "rejuvenation" process allows for improved cell growth and cloning abilities while keeping the cells' normal characteristics and functionality.
- The method ensures that modified cells can be supplied for research and clinical applications without altering their genetic makeup, potentially benefiting drug development and cell therapy.
Article Synopsis
- - The study focused on fully human antibody-producing TC-mAb mice to generate therapeutic monoclonal antibodies (mAbs) targeting the tumor antigen, epithelial cell adhesion molecule (EpCAM).
- - Researchers analyzed 377 mAb clones, finding that the EpCL region of EpCAM is more immunogenic than the EpRE region, confirming previous studies.
- - They also developed a method to label mAbs with a cytotoxic agent, DM1, and demonstrated that both high-affinity and low-affinity mAbs can effectively kill colon cancer cells, highlighting the potential of TC-mAb mice for identifying candidates for antibody-drug conjugates (ADCs).
Pain is more prevalent in women for reasons that remain unclear. We have identified a mechanism of injury-free nociceptor sensitization and opioid-induced hyperalgesia (OIH) promoted by prolactin (PRL) in females. PRL signals through mutually inhibitory long (PRLR-L) and short (PRLR-S) receptor isoforms, and PRLR-S activation induces neuronal excitability.
View Article and Find Full Text PDFThe collapsin response mediator protein 2 (CRMP2) has emerged as a central node in assembling nociceptive signaling complexes involving voltage-gated ion channels. Concerted actions of post-translational modifications, phosphorylation and SUMOylation, of CRMP2 contribute to regulation of pathological pain states. In the present study, we demonstrate a novel role for CRMP2 in spinal nociceptive transmission.
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