Human Neutrophils Produce Antifungal Extracellular Vesicles against Aspergillus fumigatus.

Polymorphonuclear granulocytes (PMNs) are indispensable for controlling life-threatening fungal infections. In addition to various effector mechanisms, PMNs also produce extracellular vesicles (EVs). Their contribution to antifungal defense has remained unexplored.

Enolase From Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen.

The opportunistic fungal pathogen can cause severe infections, particularly in immunocompromised individuals. Upon infection, faces the powerful and directly acting immune defense of the human host. The mechanisms on how evades innate immune attack and complement are still poorly understood.

Aspf2 From Recruits Human Immune Regulators for Immune Evasion and Cell Damage.

The opportunistic fungal pathogen can cause life-threatening infections, particularly in immunocompromised patients. Most pathogenic microbes control host innate immune responses at the earliest time, already before infiltrating host immune cells arrive at the site of infection. Here, we identify Aspf2 as the first Factor H-binding protein.