Publications by authors named "Iona S Easthope"
Effective use of adenovirus-5 (Ad5) in cancer therapy is heavily dependent on the degree to which the virus's natural tropism can be subverted to one that favours tumour cells. This is normally achieved through either engineering of the viral fiber knob or the use of bispecific adaptors that display both adenovirus and tumour antigen receptors. One of the main limitations of these strategies is the need to tailor each engineering event to any given tumour antigen.
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- * It explains that while glucosidases I and II are primarily responsible for this process, endo-α-mannosidase can act as a backup in certain situations, especially when glucosidases are inhibited.
- * The research found that in bovine cells, the endomannosidase has a limited substrate range and is genetically regulated, suggesting it is adapted to function effectively even when other enzymes have reduced activity.