Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36 TeV with the ATLAS Detector at the LHC.

This Letter presents a search for highly ionizing magnetic monopoles in 262  μb^{-1} of ultraperipheral Pb+Pb collision data at sqrt[s_{NN}]=5.36  TeV collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion data.

[Conversion Surgery for Pancreatic Cancer].

Pancreatic cancer is known as a disease with an extremely poor prognosis. Although surgery is the only curative treatment, most pancreatic cancer is already advanced at the time of diagnosis. With advances in multidisciplinary treatment such as chemotherapy, radiation therapy, and heavy-ion therapy, more cases of unresectable(UR)pancreatic cancer are being treated with surgery in recent years.

Pericytes Are Odontoblast Progenitor Cells Depending on ER Stress.

Odontoblasts are terminally differentiated cells that exhibit mechanosensitivity and mineralization capacity. Mechanosensitive ion channels such as Piezo1 are present in odontoblasts and are associated with their physiological functions via Ca signaling. Both Ca signals via Ca influx from mechanosensitive ion channels and Ca release from Ca stores function as secondary messenger systems for various biological phenomena.

Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease.

The plasma membrane covering the primary cilium has a diverse accumulation of receptors and channels. To ensure the sensor function of the cilia, the ciliary membrane has higher cholesterol content than other cell membrane regions. A peroxisomal biogenesis disorder, Zellweger syndrome, characterized by polycystic kidney, is associated with a reduced level of ciliary cholesterol in cells.

Expression and functional analysis of mouse chitinases without the ZZ domain of Staphylococcus aureus Protein A.

Chitinase plays a role in mammalian immune responses, particularly in the degradation of fungal cell walls. The aim of the present study was to express and characterize recombinant mouse chitotriosidase (Chit1) and acidic mammalian chitinase (AMCase) without the ZZ domain, a domain that may interfere with immunological analyses. We successfully expressed recombinant chitinases without the ZZ domain (Chit1-V5-His and AMCase-V5-His) as a soluble protein from an expression vector pET21a in the Escherichia coli Rosetta-gami B (DE3) strain.

Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake.

Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes with the total energy expenditure (TEE). In this study, we used the International Atomic Energy Agency Doubly Labeled Water Database to derive a predictive equation for TEE using 6,497 measures of TEE in individuals aged 4 to 96 years.

Expression of Recombinant Human α-Glucosidase in HEK293 Cells.

In mammals, intestinal α-glucosidase exists as a maltase-glucoamylase complex (MGAM) and a sucrase-isomaltase complex (SI). In this study, we transiently expressed human MGAM and SI in human embryonic kidney 293 (HEK293) cells. At pH 6.

Hyperactivation of human acidic chitinase (Chia) for potential medical use.

Accumulation of environmental chitin in the lungs can lead to pulmonary fibrosis, characterized by inflammatory infiltration and fibrosis in acidic chitinase (Chia)-deficient mice. Transgenic expression of Chia in these mice ameliorated the symptoms, indicating the potential of enzyme supplementation as a promising therapeutic strategy for related lung diseases. This study focuses on utilizing hyperactivated human Chia, which exhibits low activity.

Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity.

Unfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization. Prolonged UPR activation is associated with the development and progression of various diseases, making it essential to understanding the redox regulation of PERK.

Efficacy of combining soluble calcium and pyrophosphate with sodium fluoride in inhibiting enamel caries progression: An in vitro study.

Objective: This study aimed to compare the effects of a combination of sodium fluoride, soluble calcium, and pyrophosphate (FCaP) versus fluoride alone in inhibiting enamel caries progression.

Design: Different FCaP solutions were prepared, and two were selected for testing (FCaP-1: F = 76 mmol/L, Ca = 7.6 mmol/L, P = 7.

Electrochemical lithium-ion insertion/extraction reactions of multilayered graphene with random twist angles.

A multilayer graphene film with random twist angles between layers (TAGr) on SiC(0001̄) shows six pairs of redox peaks for Li insertion/extraction reaction. The distributed twisted angle in TAGr regulates Li insertion sites, and smaller -axis expansion (3%) is realized by Li insertion.

Experimental and Theoretical Investigation of Anisotropic Proton Conduction in Two-Dimensional Metal-Organic Frameworks.

Two-dimensional (2D) materials are known for their potential to exhibit anisotropic transport properties due to their layered structures. However, the anisotropic ion conduction of 2D metal-organic frameworks (MOFs) has been rarely explored. In this study, we investigated the anisotropic proton conduction along the in-plane and stacking directions of two analogs of undulating 2D MOFs: [Mn(salen)][Pt(CN)]·HO () and [Mn(salen)][PtI(CN)]·HO ().

TEMPO-oxidized cellulose nanofiber hydrogel electrolyte for rechargeable Zn-ion batteries.

A hydrogel composed of TEMPO-oxidized cellulose and zinc perchlorate is proposed as an electrolyte for rechargeable Zn-ion battery. The non-flowable solid-like electrolyte has strong shear-thinning behavior, room temperature conductivity of ∼10 S cm, and stable Zn/electrolyte interphase. The Zn-ion gel-battery with a β-MnO cathode delivers over 100 mA h g at 1.

Optical-stimulated luminescence properties of undoped and Eu-doped LiCl transparent ceramics synthesized by spark plasma sintering method.

The undoped and Eu-doped LiCl transparent ceramics were synthesized, and their photoluminescence (PL) and optical stimulated luminescence (OSL) properties were evaluated. The PL properties of the undoped sample revealed as emission band due to a defect center. Additionally, the Eu-doped samples exhibited an emission band due to the 5d-4f transitions of Eu ions.

Determinant of factors associated with water requirement measured using the doubly labelled water method among older Japanese adults.

Objective: Water is an essential nutrient for all organisms and is important for maintaining life and health. We aimed to develop a biomarker-calibrated equation for predicting water turnover (WT) and pre-formed water (PW) using the doubly labelled water (DLW) method.

Design: Cross-sectional study.

Hereditary spastic paraplegia and extensive leukoencephalopathy: a case report of a unique phenotype associated with a GJB1/Cx32 p.Pro174Ser variant.

Background: Pathogenic variants in Gap junction protein beta 1 (GJB1), which encodes Connexin 32, are known to cause X-linked Charcot-Marie-Tooth disease (CMTX), the second most common form of CMT. CMTX presents with the following five central nervous systems (CNS) phenotypes: subclinical electrophysiological abnormalities, mild fixed abnormalities on neurological examination and/or imaging, transient CNS dysfunction, cognitive impairment, and persistent CNS manifestations.

Case Presentation: A 40-year-old Japanese male showed CNS symptoms, including nystagmus, prominent spastic paraplegia, and mild cerebellar ataxia, accompanied by subclinical peripheral neuropathy.

Gelation of gellan induced by trivalent cations and coexisting trivalent with monovalent cations studied by rheological and DSC measurements.

The effect of trivalent cation Fe on the gelation process of a sodium salt form of gellan (DG, deacylated gellan gum) was investigated by rheology and DSC studies. On addition of a fairly low concentration of Fe (1 mM), both the complex modulus (G*) of a 1.0 % DG solution in gel state and the sol-gel transition temperature (T) slightly decreased.

Spectral modulation of B850 bacteriochlorophyll a in light-harvesting complex 2 from purple photosynthetic bacterium Thermochromatium tepidum by detergents and calcium ions.

Spectral variations of light-harvesting (LH) proteins of purple photosynthetic bacteria provide insight into the molecular mechanisms underlying spectral tuning of circular bacteriochlorophyll (BChl) arrays, which play crucial roles in photoenergy conversion in these organisms. Here we investigate spectral changes of the Q band of B850 BChl a in LH2 protein from purple sulfur bacterium Thermochromatium tepidum (tepidum-LH2) by detergents and Ca. The tepidum-LH2 solubilized with lauryl dimethylamine N-oxide and n-octyl-β-D-glucoside (LH2 and LH2, respectively) exhibited blue-shift of the B850 Q band with hypochromism compared with the tepidum-LH2 solubilized with n-dodecyl-β-D-maltoside (LH2), resulting in the LH3-like spectral features.

Growth of metal nanowire forests controlled through stress fields induced by grain gradients.

Pure metal nanowires (NWs) are one-dimensional nanomaterials with distinctive properties for various applications. Nevertheless, mass-growth forests have not been developed because of vapor pressure limitations, chemical reduction problems, or both. We succeeded in the mass growth of aluminum (Al) NW forests at desired locations by controlling atomic diffusion within the solid film.

Ferroelectricity Induced by a Combination of Crystallographic Chirality and Axial Vector.

Ferroelectric materials compatible with magnetism and/or conductive properties provide a platform for exploring unconventional phenomena, such as the magnetoelectric effect, nonreciprocal responses, and nontrivial superconductivity. Though recent studies on multiferroics have offered several approaches, the search for magnetic and/or conducting ferroelectric materials is still a challenging issue under the traditional "d-ness" rule, refusing active d electrons. Here, we propose the emergence of ferroelectricity through a combination of crystallographic chirality and axial vector, accepting even non-d magnetic ions.

Hydroxyl radical scavenging and chemical repair capabilities of positively charged peptides (PCPs): a pulse radiolysis study.

Pulse radiolysis was employed to investigate fundamental radiation chemical reactions, which are essential in the radiation protection of DNA. Two positively charged peptides (PCPs), histidine-tyrosine-histidine (His-Tyr-His) and lysine-tyrosine-lysine (Lys-Tyr-Lys), as well as the amino acids that constitute them, were involved. The reaction rate constants for tyrosine (Tyr), histidine (His), lysine (Lys), His-Tyr-His, and Lys-Tyr-Lys with OH radicals (OH) were (1.