The Radiotherapy of Locally Advanced Esophageal Cancer of Inoperable Forms with Escalated Dose of 66-70 Gy.

Squoamous cell carcinoma and adenocarcinoma account for more than 90% of all esophageal cancer cases. The total dose recommended in the actual NCCN guidelines is 50.4 Gy in 1,8 Gy fractions for the treatment of an esophageal cancer, a dose who never cure a macroscopic tumor.

The Remodeling in Advanced Breast Cancer Radiotherapy.

New concepts had to be developed since the progress in diagnostic methods, tumor characterization and progress in treatment delivery (more aggressive surgery and radiotherapy) made possible new approaches for locally advanced breast cancer. The process of remodeling is now a reality and the local cure of locally advanced tumor by only high dose radiotherapy is now possible. Based on modern irradiation techniques as IMRT, VMAT or Tomotherapy, target volume conformal dose distributions delivered to complex targets made possible the "remodeling" process at the soft and/or bone tissue.

New Language and Old Problems in Breast Cancer Radiotherapy.

New developments in breast cancer radiotherapy make possible new standards in treatment recommandations based on international guidelines. Developments in radiotherapy irradiation techniques from 2D to 3D-Conformal RT and to IMRT (Intensity Modulated Arc Therapy) make possible to reduce the usual side effects on the organs at risk as: skin, lung, miocard, bone, esophagus and brahial plexus. Dispite of all these progresses acute and late side effects are present.

[Presentation of a 3D conformal radiotherapy technique for head-and-neck tumors resulting in substantial protection of the parotid glands].

Purpose: The aim of this study was to improve the irradiation technique for the treatment of head-and-neck tumors and, in particular, to make use of the advantages found in modern 3D planning to protect the parotid glands.

Patients And Methods: For this investigation the 3D dataset of a standard patient with oropharyngeal carcinoma of UICC stage IVA was used. In the CT scans (slice thickness 5 mm) the planning target volume (PTV), the boost volume and both parotids were delineated.

Open-label simultaneous radio-chemotherapy of glioblastoma multiforme with topotecan in adults.

Background: Due to its radioresistance, the prognosis of glioblastoma multiforme (GBM) remains poor. Therefore, we investigated the impact of simultaneous radio-chemotherapy with topotecan (Hycamtin) on clinical outcome, tolerability and quality of life.

Patients And Methods: In this multicenter trial, 60 patients (19 females, 41 males) with histologically proven (5x biopsy, 31x subtotal resection, 24x total resection) GBM were included.