Grape seed proanthocyanidins prevent H O -induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells.

Grape proanthocyanidins are compounds widely ingested in the diet. This study evaluated their effects on mitochondrial function, apoptosis, and sirtuin 1 and 3 expressions in HEK-293 cells exposed to H O . High-resolution mass spectrometry and high-performance liquid chromatography characterized the proanthocyanidins extract and the presence of procyanidins B and C was detected.