Publications by authors named "Ioannis Mavroeidis"
Background: The noncoding antisense transcript for β-secretase-1 () is a long noncoding RNA with a pivotal role in the regulation of amyloid-β (Aβ). We aimed to explore the clinical value of expression in atherosclerotic cardiovascular disease (ASCVD).
Methods: Expression of and its target, β-secretase 1 () mRNA, was measured in peripheral blood mononuclear cells derived from 434 individuals (259 without established ASCVD [non-CVD], 90 with stable coronary artery disease [CAD], and 85 with acute coronary syndrome).
Article Synopsis
- The study aimed to explore if carotid-to-femoral pulse wave velocity (cf-PWV), an indicator of arterial stiffness, is linked to coronary artery disease (CAD) and diastolic dysfunction in elderly high-risk patients compared to younger individuals.
- Data from 192 high-risk patients who underwent coronary artery angiography were analyzed, measuring cf-PWV and indices of diastolic dysfunction through echocardiography.
- Results indicated that while cf-PWV was associated with CAD and diastolic dysfunction in patients under 65, this correlation was not observed in elderly patients, suggesting arterial stiffness measurement may not be clinically useful for this older demographic.