A Flow Sensing Device Formed Exclusively by Employing Additive Manufacturing for On-Site Fabrication Aboard a Ship.

This work concerns the design, fabrication, and testing of a novel air-flow sensor employing exclusively additive manufacturing that can be fabricated on-site, aboard a ship, or in a similarly remote area, without relying on external manufacturing facilities. The developed device's principle of operation is based on vortex shedding; its novelty focuses on employing solely additive manufacturing technology, for the manufacturing-in a single process step-of all the sensor's main elements. In more detail, the required flow-shaping housing, the appropriate piezoresistive sensing element, and the electrical interconnection pads are all constructed in a single process step, through standard Fused Deposition Modeling (FDM) 3D technology.

Remitting-relapsing multiple sclerosis patient refractory to conventional treatments and bone marrow transplantation who responded to natalizumab.

Bone marrow transplantation (BMT) was introduced as a treatment option 15 years ago for severe, drug-resistant multiple sclerosis (MS). Up until now, BMT has been undertaken in relatively few patients worldwide, with moderate success, and recent studies suggest that patients with early, highly aggressive MS benefit most from this treatment. In this work, we determined peripheral blood lymphocyte populations in a patient (patient A) with remitting-relapsing multiple sclerosis (RR-MS), refractory to conventional treatments, and who underwent BMT, relapsed, and has been treated with natalizumab for the last 22 months.

Immunotherapy for multiple sclerosis: basic insights for new clinical strategies.

Multiple Sclerosis (MS) is a chronic inflammatory degenerative disease of the central nervous system (CNS), first described over 100 years ago. MS is a clinically heterogeneous disease with an increasing incidence over time, and a population prevalence that increases with distance from the equator. It is postulated that environmental factors such as diet and population-specific genetics, influence the distribution of MS.