Burn wound angiogenesis is increased by exogenously administered recombinant leptin in rats.

Background: Leptin is a potent direct angiogenic factor that stimulates endothelial cell migration and activation in vitro and angiogenesis in vivo. In addition, leptin has been discussed to play an important role in angiogenesis, as it promotes the formation of new blood vessels.

Purpose: The effect of exogenously administered leptin on the healing process of a full tissue burn wound model.