Publications by authors named "Ioannis Deligiannis"
Background & Aims: Polyploidy in hepatocytes has been proposed as a genetic mechanism to buffer against transcriptional dysregulation. Here, we aim to demonstrate the role of polyploidy in modulating gene regulatory networks in hepatocytes during ageing.
Methods: We performed single-nucleus RNA sequencing in hepatocyte nuclei of different ploidy levels isolated from young and old wild-type mice.
Article Synopsis
- - The study highlights the unique molecular characteristics of bone marrow in the skull, contrasting it with other bones and demonstrating its significant role in immune responses within the brain and meninges.
- - Researchers found that mouse skull marrow exhibits a distinct transcriptomic profile, particularly in relation to neutrophils, and similar proteomic differences were observed in human skull marrow.
- - Advanced imaging techniques reveal the structural connections between the skull and meninges, and the skull marrow's inflammatory response correlates with neurological disorders, suggesting its potential in diagnosing and treating brain diseases.
Objective: Fibrotic organ responses have recently been identified as long-term complications in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent driving features of progressive non-alcoholic fatty liver disease (NAFLD), ranging from simple steatosis and non-alcoholic steatohepatitis (NASH) to fibrosis. Effective pharmacological regimens to stop progressive liver disease are still lacking to-date.
View Article and Find Full Text PDFUltrasound is the first imaging modality to be performed in emergency conditions of the scrotum. The commonest pathologic entities are divided into the 4 following groups: torsion, trauma, infection, and tumors. Sonographic examination should be performed as soon as possible to ensure fast diagnosis and treatment.
View Article and Find Full Text PDFStudy Objective: To evaluate the prevalence of sexual activity and contraception methods used by Greek adolescents. To assess the effect of various factors in the decision making on sexual activity.
Design: A cross-sectional study design was applied.