Publications by authors named "Ioana A Ghiu"
Article Synopsis
- The study investigates the effects of the Ala54Thr mutation in the FABP2 gene on glucose regulation and lipid metabolism in sedentary, nondiabetic individuals on a low-fat diet.
- It finds that carriers of the Thr54 variant exhibit lower glucose tolerance, higher fasting glucose levels, and reduced insulin sensitivity compared to individuals with the Ala54 variant.
- Additionally, Thr54 carriers showed increased lipid oxidation rates, suggesting a potential link between this mutation and glucoregulatory dysfunction.
The present study sought to investigate, in sedentary men and women, (a) whether a common functional gene variant (peroxisome proliferator-activated receptor-gamma2 [PPARgamma2] Pro12Ala) predicts insulin action and (b) whether improvements in insulin action in response to endurance exercise training are associated with PPARgamma2 Pro12Ala. Sedentary, 50- to 75-year-old men and women (N = 73) were genotyped and underwent oral glucose tolerance tests (OGTTs) before and after 6 months of endurance training. At baseline, men heterozygous for the Pro12Ala variant had a greater OGTT insulin area under the curve (AUC) as compared with Pro12 homozygous men (P = .
View Article and Find Full Text PDFFunctional ATP-sensitive potassium (K(ATP)) channels can be reconstituted by expression of various combinations of different pore-forming subunits (Kir6.1 and Kir6.2) and sulfonylurea receptor (SUR) subunits.
View Article and Find Full Text PDFArticle Synopsis
- A polymorphism in the IL-6 gene linked to diabetes and insulin resistance was studied in sedentary older adults undergoing aerobic exercise training.
- The study involved 87 participants, with differences noted in fasting glucose levels based on the IL-6 genotype, particularly between the CC and GG groups.
- Results showed that only the GG genotype group experienced significant improvements in glucose tolerance, indicating that the IL-6 gene polymorphism may influence how individuals respond to exercise training in terms of glucose metabolism.*
We assessed the effects of coagulation factor VII (FVII) gene polymorphisms, lipid-related polymorphisms, and exercise training-induced plasma lipoprotein lipid changes on FVII level changes with exercise training in middle- to older-aged men and women. Forty-six healthy sedentary men and women were stabilized on a low-fat diet and then underwent baseline testing, 6 mo of endurance exercise training, and final testing. Plasma FVII-Ag levels decreased with exercise training (106.
View Article and Find Full Text PDF