Publications by authors named "Ioan Ṣtefan Florian"

Background: Intrathoracic migration of a ventriculoperitoneal shunt (VPS) is a phenomenally rare complication, with the supradiaphragmatic intercostal variant even more so. Whereas it can prove debilitating or even fatal via massive hydrothorax, the causative mechanism and proper management of this occurrence are undefined.

Case Presentation: A 17-month-old girl who had undergone VPS insertion at one month of age was brought to our department for somnolence and dyspnea, which had a sudden onset.

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  • * Patients in the sitting position were generally younger and experienced higher rates of anesthetic complications and hypotension compared to those in the park-bench position.
  • * Despite the increased anesthetic risks in the sitting position, it was linked to lower postoperative mortality rates, highlighting the importance of evaluating each patient's risks when choosing their surgical position.
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We describe the case of a 72-year-old man who presented with signs of increased intracranial pressure, right-sided motor deficit, and repeated episodes of epilepsy due to a left frontal arteriovenous malformation (AVM) with a large superficial draining vein. Despite great efforts to protect the vein from the start, it ruptured shortly after we removed the bone flap. This required rigorous hemorrhage control, which in turn led to profuse bleeding from the nidus throughout the process of the dissection and coagulation of the arterial feeders.

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Background And Aims: The purpose of this study is to analyze the sitting position and the park-bench position for intra-anesthesia complications in pediatric patients undergoing neurosurgery for posterior fossa lesions. Our goal is to highlight the risks associated with each of these positions under general anesthesia to aid in clinical decision making for optimal patient outcomes with regard to postoperative complications.

Methods: We retrospectively reviewed 41 pediatric patients (1 to 18 years old) undergoing posterior fossae surgery in the sitting (32) and park-bench (9) positions between January 2015 and December 2021.

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  • Tumor-like lesions at the craniovertebral junction can present similarly to tumors, and this study analyzes common types like epidermoids, dermoids, and neurenteric cysts through a retrospective review of 170 patients across 119 reports.
  • Neurenteric cysts were the most prevalent (81.2%), and complications occurred in 27.2% of cases, with 75.2% of patients having excellent outcomes and low recurrence rates (12%).
  • The research highlights the significance of total resection in reducing recurrence and emphasizes that factors like patient age, associated anomalies, and preoperative planning greatly impact surgical results.
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Objective: Decompressive craniectomy (DC) serves as a vital life-saving intervention, demonstrating efficacy in reducing intracranial pressure (ICP). However, its efficacy hinges on meticulous surgical execution, perioperative management, and vigilance toward potential complications. The incidence of complications associated with DC plays a pivotal role in determining its superiority over medical management for patients experiencing intracranial hypertension following traumatic brain injury (TBI).

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Background: Sofia Ionescu (1920-2008) was the first female neurosurgeon in the world, pioneering her field with skill, dedication, and humility. Born in Romania, she began her career amid the tumult of World War II, performing her first neurosurgical procedure in 1944. Despite initial skepticism, her talent and commitment earned her recognition, culminating in her acknowledgment as the first female neurosurgeon by the World Federation of Neurosurgical Societies in 2005.

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: A magnetic resonance imaging (MRI) scan is part of the diagnostic protocol in pituitary adenoma patients. The goal of the present study is to present and analyse the MRI appearances of the sphenoid sinus (SS) in patients with non-functioning pituitary adenoma (NFPA). : This is a retrospective case-control study conducted between January 2015 and December 2023 in a tertiary referral hospital.

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Background: The role of surgery in the management of malignant gliomas has been feverishly deliberated after the publication of the first expansive case series, the last two decades reinvigorating the discussion regarding the value of total removal in improving survivability. Despite numerous technologies being implemented to increase the resection rates of malignant gliomas, the role of surgical experience has been largely overlooked. This article aims to discuss the importance of a single surgeon's experience in treating high-grade gliomas over a period of 20 years.

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Introduction: Planning cranioplasty (CPL) in patients with suspected or proven post-traumatic hydrocephalus (PTH) poses a significant management challenge due to a lack of clear guidance.

Research Question: This project aims to create a European document to improve adherence and adapt to local protocols based on available resources and national health systems.

Methods: After a thorough non-systematic review, a steering committee (SC) formed a European expert panel (EP) for a two-round questionnaire using the Delphi method.

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Background And Aims: To emphasize the importance of laboratory dissections in perfecting surgical techniques. In this paper, we describe the technical details on rabbit dissection for practical applications.

Methods: Four New Zealand rabbits were distributed into two groups and underwent anastomosis between the Facial Nerve and Ansa Cervicalis (group 1) and between the Facial Nerve and Hypoglossal Nerve (group 2).

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  • - The study aimed to investigate how prior anticoagulant treatment affects the characteristics of intracranial hematomas in patients with traumatic brain injury, specifically focusing on subdural hematomas.
  • - A total of 135 patients were analyzed, revealing that those on anticoagulant therapy tended to have larger and more severe acute subdural hematomas, indicated by significant midline shift and increased hematoma thickness observed on CT scans.
  • - The findings suggest that while anticoagulants alter imaging features of subdural hematomas, they do not significantly correlate with other types of brain injuries or conditions like cranial fractures and brain swelling.
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Introduction: Ventriculomegaly (VM) is a fetal brain malformation which may present independently (isolated form) or in association with different cerebral malformations, genetic syndromes or other pathologies (non-isolated form).

Methods: This paper aims to study the effect of ventriculomegaly on the internal tridimensional architecture of fetal brains by way of Klingler's dissection. Ventriculomegaly was diagnosed using fetal ultrasonography during pregnancy and subsequently confirmed by necropsy.

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Traumatic brain injury (TBI) can have severe consequences in most cases. Many therapeutic and neurosurgical strategies have been improved to optimize patient outcomes. However, despite adequate surgery and intensive care, death can still occur during hospitalization.

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Intracranial epidermoid cysts are benign slow-growing ectodermal inclusions that account for less than 1% of all intracranial tumors. We retrospectively reviewed 36 such cases to evaluate the demographic characteristics, clinical manifestations, anatomical distribution, surgical management, and treatment outcome of these tumors. Additionally, we sought to identify the relationship between median or paramedian cistern tumor localization and clinical parameters, such as recurrence risk, hospitalization duration, and postoperative complication rates.

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Introduction And Importance: AVM and MM represent neurosurgical challenges, not only when involving eloquent brain, but also by posing a significant intraoperative haemorrhagic risk. It is a challenge in itself to establish a proper differential diagnosis between the two lesions, especially since they require distinct interventional plan of action. We present the case of a patient initially diagnosed by specialists with an intracranial AVM, which was revealed intraoperatively to be in fact an MM.

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For decades, patients with facial asymmetry have experienced social interaction difficulties, leading them to seek treatment in the hope of restoring facial symmetry and quality of life. Researchers evaluated numerous surgical techniques, but achieving results remains a significant hurdle. Specifically, anastomosis between the ansa cervicalis (AC) and facial nerve (FN) can hinder the patient's physical appearance.

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Hydrocephalus is a complex pathology that can have a significant impact on the quality of life in all age groups. Cerebrospinal fluid (CSF) diversions from the lateral ventricle to the peritoneal cavity are regarded as the treatment of first intent, but they have a high revision rate, and there are multiple factors which can impair their proper insertion and function. One of the many alternatives to peritoneal shunting is redirecting the CSF towards the renal system.

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Article Synopsis
  • The study focused on validating an algorithm for predicting isocitrate dehydrogenase (IDH) status in gliomas, which is crucial for prognosis but typically requires invasive tests.
  • Researchers used preoperative MRI images from 21 adult patients and found that their validation test achieved a 76% accuracy rate, indicating reasonable effectiveness but not yet suitable for clinical use.
  • The study highlights the ongoing exploration of radiogenomics as a promising research area that could improve non-invasive diagnostic methods in glioma management.
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Aneurysms and vascular malformations of the brain represent an important source of intracranial hemorrhage and subsequent mortality and morbidity. We are only beginning to discern the involvement of microglia, the resident immune cell of the central nervous system, in these pathologies and their outcomes. Recent evidence suggests that activated proinflammatory microglia are implicated in the expansion of brain injury following subarachnoid hemorrhage (SAH) in both the acute and chronic phases, being also a main actor in vasospasm, considerably the most severe complication of SAH.

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  • Brain arteriovenous malformations (BAVMs) and cerebral cavernous malformations (CCMs) are unusual vascular malformations in the brain that can rupture unpredictably, complicating their management due to their diverse characteristics and unclear underlying mechanisms.
  • Recent research has highlighted the role of microRNAs (miRNAs), small non-coding RNA molecules, in influencing the occurrence and development of BAVMs and CCMs, despite many unanswered questions about how they function.
  • The review identified specific miRNAs associated with BAVMs and CCMs, noting that certain miRNAs were downregulated or upregulated, which could provide insight into potential treatment strategies and enhance understanding of these conditions.
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In the present study, we aimed to assess and analyze the predictive factors of 30-day mortality in patients with acute subdural hematoma (ASDH) who underwent surgical intervention after traumatic brain injury (TBI). We conducted a retrospective study, which included a cohort of 135 consecutive patients diagnosed with ASDH who required surgical evacuation. We assessed the demographic and clinical data, the imaging data of the hematoma described by preoperative computed tomography (CT) and the type of neurosurgical intervention for hematoma evacuation via either craniectomy or craniotomy.

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