Malioxamycin, a new antibiotic with spheroplast-forming activity. I. Producing organism, fermentation, isolation and characterization.

Strain No. 15748, identifies as Streptomyces lydicus, produces a new antibiotic malioxamycin. Malioxamycin is a water-soluble, amphoteric antibiotic with low molecular weight, having a valine and a malic acid moieties in its structure.

Existence of the bound form of prolipoprotein in Escherichia coli B cells treated with globomycin.

A murein-bound form of prolipoprotein was found in the cell envelope fraction of globomycin-treated Escherichia coli B. We suggest therefore that proteolytic cleavage of prolipoprotein to mature lipoprotein is not essential for the transpeptidation of the lipoprotein to peptidoglycan.

Globomycin, a new peptide antibiotic with spheroplast-forming activity. III. Structural determination of globomycin.

The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation. Globomycin is a new cyclic peptide antibiotic composed of L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid. Among these components, L-allo-threonine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid are novel components from natural products.

Globomycin, a new peptide antibiotic with spheroplast-forming activity. I. Taxonomy of producing organisms and fermentation.

A new peptide antibiotic, globomycin, was found to be produced by four different strains of the actinomycetes. They were identified as Streptomyces halstedii No. 13912, Streptoverticillium cinnamoneum No.

Globomycin, a new peptide antibiotic with spheroplast-forming activity. II. Isolation and physico-chemical and biological characterization.

The peptide antibiotic globomycin was extracted from the culture filtrate of Streptomyces halstedii No. 13912, purified on silica-gel columns and crystallized from acetonitrile to give colorless needles. It is a neutral substance with m.