Publications by authors named "Intisar A"

The WRINKLED1 (WRI1) transcription factor controls carbon flow in plants through regulating the expression of glycolysis and fatty acid biosynthesis genes. The role of Gossypium hirsutum WRINKLED1 (GhWRI1) in seed-oil accumulation still needs to be explored. Multiple sequence alignment of WRI1 proteins confirmed the presence of two conserved AP2 domains.

View Article and Find Full Text PDF

Numerous harmful phenolic contaminants are discharged into water that pose a serious threat to environment where two of the most important purification methodologies for the mitigation of phenolic contaminants are adsorption and photocatalysis. Besides cost, each process has drawbacks in terms of productivity, environmental impact, sludge creation, and the development of harmful by-products. To overcome these limitations, the modeling and optimization of water treatment methods is required.

View Article and Find Full Text PDF

Terminalia arjuna is an evergreen medicinal plant that belongs to the Combretaceae family of flowering plants. The bark of the plant exhibits antiviral, anticancer, hypocholesterolemic, antioxidant and antimicrobial properties. In this study, composition antibacterial activity, antioxidant activity and cytotoxicity of bark oil of Terminalia arjuna(Roxb.

View Article and Find Full Text PDF

Background: Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn's disease (CD) remains limited.

Aim: To systematically review the global variation in the rates of surgery in CD.

Methods: A comprehensive search analysis was performed using multiple electronic databases from inception through July 1, 2020, to identify all full text, randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with CD.

View Article and Find Full Text PDF

Non-biodegradable implants have undergone extensive investigation as drug delivery devices to enable advanced healthcare toward personalized medicine. However, fibroblast encapsulation is one of the major challenges in all non-biodegradable implants, besides other challenges such as high initial burst, risk of membrane rupture, high onset time, non-conformal contact with tissues, and tissue damage. To tackle such challenges, we propose a novel ultrasoft and flexible balloon-type drug delivery device for unidirectional and long-term controlled release.

View Article and Find Full Text PDF

While the world is rapidly transforming into a superaging society, pharmaceutical approaches to treat sarcopenia have hitherto not been successful due to their insufficient efficacy and failure to specifically target skeletal muscle cells (skMCs). Although electrical stimulation (ES) is emerging as an alternative intervention, its efficacy toward treating sarcopenia remains unexplored. In this study, we demonstrate a silver electroceutical technology with the potential to treat sarcopenia.

View Article and Find Full Text PDF
Article Synopsis
  • The gut microbiome, which is the collection of bacteria in our digestive system, affects how people respond to medications, especially in personalized medicine.
  • Researchers are studying how the gut microbiome influences the success of new cancer treatments, like immunotherapy, particularly for pancreatic cancer, which is hard to treat.
  • New studies show that the gut bacteria can help improve the effectiveness of both traditional cancer treatments and the immune system's response to tumors, offering hope for better treatments.
View Article and Find Full Text PDF

Life on earth is dependent on clean water, which is crucial for survival. Water supplies are getting contaminated due to the growing human population and its associated industrialization, urbanization, and chemically improved agriculture. Currently, a large number of people struggle to find clean drinking water, a problem that is particularly serious in developing countries.

View Article and Find Full Text PDF
Article Synopsis
  • Natural killer (NK) cells are crucial for the innate immune response against cancer and pathogens, making them important for allogeneic cell immunotherapy.
  • Traditional methods of isolating NK cells from blood often lead to issues like low yield, high cellular stress, and increased risk of complications, thereby affecting their effectiveness.
  • A new automated system using continuous centrifugal microfluidics (CCM) has been developed to isolate NK cells more efficiently, providing higher yield and purity while reducing cellular stress, promising better outcomes for immune cell therapies.
View Article and Find Full Text PDF

Jam Quality is a factor robustly influenced by storage conditions. The current research aimed to develop papaya jam with improved nutritional attributes, rheological profile, and shelf-life utilizing date pit powder as a functional ingredient. The effect of date pit powder on the formulated product's physicochemical, microbial, and organoleptic properties was analyzed.

View Article and Find Full Text PDF
Article Synopsis
  • Charcot-Marie-Tooth disease subtype 1A (CMT1A) is a genetic nerve disease caused by too much of a protein called PMP22, which can damage nerve cells.
  • Scientists studied how using electrical stimulation (ES) might help improve the problems caused by this disease in lab-grown Schwann cells, which are important for nerve function.
  • Their research found that applying ES at a specific frequency helped reduce PMP22 buildup and improved the expression of proteins needed to repair the nerve covering, suggesting that ES could be a promising treatment for CMT1A.
View Article and Find Full Text PDF

Although many efforts are undertaken to treat peripheral demyelinating neuropathies based on biochemical interventions, unfortunately, there is no approved treatment yet. Furthermore, previous studies have not shown improvement of the myelin membrane at the biomolecular level. Here, an electroceutical treatment is introduced as a biophysical intervention to treat Charcot-Marie-Tooth (CMT) disease-the most prevalent peripheral demyelinating neuropathy worldwide-using a mouse model.

View Article and Find Full Text PDF

Progress in neurological research has experienced bottlenecks owing to the limited availability of purified primary neurons. Since neuronal cells are non-proliferative, it is necessary to obtain purified neurons from animal models or human patients for experimental work. However, currently available methods for purifying primary neurons are time-consuming (taking approximately 1 week), and suffer from insufficient viability and purity.

View Article and Find Full Text PDF

The current study comprises the successful synthesis of a Ni-WO@g-CN composite as an efficient and recoverable nanocatalyst for oxidative desulfurization of both model and real fuel oils. The physiochemical characterization of the synthesized composite was confirmed via Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy, and thermogravimetric analysis. SEM results showed that Ni-WO particles were well-decorated on the g-CN surface with an interesting morphology as appeared on the surface like spherical particles.

View Article and Find Full Text PDF

The present study encompasses the application of cost effective, organo-modified bentonite material for efficient desulfurization of model oil and real fuel. For the adsorptive desulfurization of oil, dibenzothiophene (DBT) was used as model compound. Various experimental parameters (time, temperature, adsorbent-amount and DBT concentration) were thoroughly investigated.

View Article and Find Full Text PDF

For the first time, two new kinds of inorganic-organic hybrid nanomaterials (BiWO@rGO and Cu-WO@rGO) were fabricated by simple hydrothermal treatment and employed for green and efficient oxidative desulfurization of real fuel. The characterization of newly synthesized nanocomposites was performed by SEM, EDX, P-XRD, FT-IR and TGA. SEM and XRD analyses revealed well decoration of dopants (Cu-WO and Bi-WO) on the surface of rGO with a crystallite size of <50 nm.

View Article and Find Full Text PDF

Increasing demand of food and agriculture is leading us towards the increasing use and introduction of pesticides to the environment. The upright increase of pesticides in water and associated adverse effects have become a great point of concern to develop proficient methods for their mitigation from water. Various different methods have been traditionally employed for this purpose.

View Article and Find Full Text PDF

As the myelin sheath is crucial for neuronal saltatory conduction, loss of myelin in the peripheral nervous system (PNS) leads to demyelinating neuropathies causing muscular atrophy, numbness, foot deformities and paralysis. Unfortunately, few interventions are available for such neuropathies, because previous pharmaceuticals have shown severe side effects and failed in clinical trials. Therefore, exploring new strategies to enhance PNS myelination is critical to provide solution for such intractable diseases.

View Article and Find Full Text PDF

Conversion of nitroaniline (NA), a highly toxic pollutant that has been released into aquatic systems due to unmanaged industrial development in recent years, into the less harmful or a useful counterpart is the need of the hour. Various methods for its conversion and removal have been explored. Owing to its nominal features of advanced effectiveness, the chemical reduction of 4-NA using various different nanocatalytic systems is one such approach that has attracted tremendous interest over the past few years.

View Article and Find Full Text PDF

Pipetting techniques play a crucial role in obtaining reproducible and reliable results, especially when seeding cells on small target areas, such as on microarrays, biochips or microfabricated cell culture systems. For very rare cells, such as human primary skeletal muscle cells (skMCs), manual (freehand) cell seeding techniques invariably result in nonuniform cell spreading and heterogeneous cell densities, giving rise to undesirable variations in myogenesis and differentiation. To prevent such technique-dependent variation, we have designed and fabricated a simple, low-cost pipet guidance device (PGD), and holder that works with hand-held pipettes.

View Article and Find Full Text PDF

Analysis of acidic pharmaceuticals in complex biological samples is a challenging and formidable task due to the existence of interfering constituents within the sample matrices. Therefore, in order to avoid analytical column clogging and suppression/enhancement of signals of the analyte of interest, herein a simple, cost-effective and quick online ion chromatography based clean-up setup was introduced. This system was further coupled with a cost-effective homemade photochemically induced fluorimetric (PIF) setup for direct online conversion of non-fluorescent acidic pharmaceutical drugs into their respective fluorescent species.

View Article and Find Full Text PDF
Article Synopsis
  • Water contamination is a major global issue that requires effective treatment methods to maintain a clean environment and reduce competition for resources.
  • Metal and metal oxide nanoparticles (NPs) are becoming popular for water treatment due to their small size and large surface area, improving the removal of pollutants.
  • However, the use of these nanoparticles comes with significant risks, including potential toxicity, raising concerns about their long-term effects and future challenges in water purification technologies.
View Article and Find Full Text PDF

Volatile oil composition of leaves and fruits of (Roxb.) was reported for the first time. Oils were extracted by microwave assisted hydrodistillation where yield of both oils were found to be 0.

View Article and Find Full Text PDF

In this review, various methods of preparation of activated carbon from agricultural and commercial waste material are reviewed. In addition, we also discuss various activation treatments using a comparative approach. The data are organised in tabulated form for ease of comparative study.

View Article and Find Full Text PDF