Rv2617c is involved in stress response and phage infection resistance.

( is the pathogen of human tuberculosis (TB). Resistance to numerous stresses, including oxidative stress, is determinant for intracellular survival, and understanding associated mechanisms is crucial for developing new therapeutic strategies. Rv2617c has been associated with oxidative stress response when interacting with other proteins in ; however, its functional promiscuity and underlying molecular mechanisms remain elusive.

Characteristics of subtype III-A CRISPR-Cas system in Mycobacterium tuberculosis: An overview.

CRISPR-Cas systems are the only RNA- guided adaptive immunity pathways that trigger the detection and destruction of invasive phages and plasmids in bacteria and archaea. Due to its prevalence and mystery, the Class 1 CRISPR-Cas system has lately been the subject of several studies. This review highlights the specificity of CRISPR-Cas system III-A in Mycobacterium tuberculosis, the tuberculosis-causing pathogen, for over twenty years.

The Gene and Regulatory Network Involved in Ethambutol Resistance in .

Ethambutol (EMB) is used in combination with isoniazid and rifampicin for the treatment of tuberculosis caused by . However, the incidence of EMB resistance is alarming. The EMB targets the cell wall arabinan biosynthesis.

Cytokine storm in tuberculosis and IL-6 involvement.

Tuberculosis is probably the most seasoned illness of the humanity. Intricacies or subsequent death emerging from these infections are frequently connected with cytokine storm. Interleukin-6 (IL-6) plays a crucial role in the immune response to tuberculosis.

Differential Isoniazid Response Pattern Between Active and Dormant .

Isoniazid (isonicotinic acid hydrazide, INH) is an effective frontline antituberculosis drug. INH targets several processes, including mycolic acid biosynthesis, DNA synthesis, and redox potential. responds to INH stress by altering the expression level of crucial genes involved in various pathways.