Publications by authors named "Insa Thale"
Ion channels play an important role for regulation of the exocrine and the endocrine pancreas. This review focuses on the Ca-regulated K channel K3.1, encoded by the gene, which is present in both parts of the pancreas.
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- * A new compound, [F]fluoroethyltriazolyl substituted senicapoc, was tested as a PET tracer and showed promising results for imaging the K 3.1 channels in lung cancer cells in animal studies.
- * Novel senicapoc BODIPY conjugates have been developed for visualizing K 3.1 channels; these compounds demonstrate strong specificity and improved solubility, confirmed by binding studies with the channel structure.
The calcium-activated potassium channel 3.1 (K 3.1) is overexpressed in many tumor entities and has predictive power concerning disease progression and outcome.
View Article and Find Full Text PDFThe K3.1 channels, previously designated as IK1 or SK4 channels and encoded by the KCNN4 gene, are activated by a rise of the intracellular Ca concentration. These K channels are widely expressed in many organs and involved in many pathologies.
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