Growth patterns of gastric carcinoma detected by mass survey.

Two hundred and sixty-seven cases of gastric carcinoma detected by mass survey included 196 discovered at the first examination (Group A) and 71 noted at the annual sequential examination (Group B) were analyzed in terms of growth pattern and prognosis. The incidence of early carcinoma was 54.9 per cent in Group B higher than 35.

Prolonged survival of gastric cancer patients on a specific adjuvant chemotherapy.

Since 1970, there has been a remarkable improvement in Japan in the outcome of surgery for patients with gastric cancer. Not only the increased rate of detection of early gastric cancer but the standardization of the prophylactic extended lymphadenectomy (ELX) has brought about a remarkable rise in survival rate. In patients with regional lymph node metastasis, we obtained a 5 year survival rate of 39 percent in the ELX group, whereas the rate was only 18 percent in the simple gastrectomy group.

[A randomized study on the long-term adjuvant chemotherapy with ftorafur and mitomycin C for gastric cancer: the second study (III)].

The Cooperative Study Group of Surgical Adjuvant Chemotherapy for Gastric Cancer adopted, as a second cooperative study, a prospective randomized trial on three groups: MMC alone, Ftorafur alone, and a combination of MMC and Ftorafur. The number of patients subjected to this analysis was 3033. The usefulness of long-term adjuvant chemotherapy was studied, based on a follow-up period of 4 years after surgery.

[Influence of PSK on the metabolism of FT-207].

The influence of PSK on the metabolism of FT-207 was studied in patients with gastric cancer. The 5-FU concentration in the blood was determined 15 min, 30 min, 1 hour and 3 hours after intravenous injection of FT-207, 400mg. The blood level of 5-FU remained constant in 86% of patients after administration of PSK for 7 days, but decreased in 14% of patients.

Mutation causing reverse osmoregulation of synthesis of OmpF, a major outer membrane protein of Escherichia coli.

Supplementation of growth media with high concentrations of substances like sucrose results in the induction of OmpC synthesis and the suppression of OmpF synthesis. We isolated a novel mutant in which OmpF synthesis is in the opposite direction from normal osmoregulation. By transductional mapping, the mutation was localized at 75 min between malA and aroB on the Escherichia coli chromosome map where the ompR-envZ region is.

[Critical evaluation of prophylactic splenectomy in total gastrectomy for stomach cancer].

In gastric cancer surgery, an extended radical operation is commonly performed, and in cases of total gastrectomy, there is a tendency to perform splenectomy at the same time. In order to examine the value of prophylactic splenectomy in gastric cancer surgery, a comparable patient group was followed up, and it was formed that the non-splenectomized group showed a better late survival rate than the splenectomized group. Although these results do not necessarily contraindicate combined splenectomy, it seems desirable to reappraise the value of prophylactic splenectomy in cases having no metastasis in the splenic hilar and adjuvant lymph nodes.

Mortality from carcinoma after partial gastrectomy.

The mortality from cancer, excluding gastric stump cancer, was examined in 3,827 Japanese patients who had undergone partial gastrectomy for benign gastroduodenal diseases. Although no increase in gastric stump cancer had been found in a previous analysis, the number of deaths from liver, lung and colorectal cancer was significantly greater than expected. The mortality rate was also significantly increased in patients with cirrhosis of the liver.

Prophylactic portal nondecompression surgery in patients with esophageal varices. An interim report.

This is an interim report of a prospective controlled study to evaluate prophylactic surgery in 112 patients with portal hypertension and esophageal varices treated since 1980. Methods of operation were confined to those with the least influence on portal circulation, namely selective shunts and nonshunting direct interruption procedures. The bleeding rates were 19.

A new secured technique for intrahepatic cholangiojejunostomy and drainage of bile.

We designed a technique for decompression of proximal biliary tract obstruction which makes an inverted anastomosis of the intestine to the intrahepatic bile duct feasible. This approach can also be used to prepare a pancreaticointestinal anastomosis.

Simultaneous occurrence of primary carcinoma and chondrosarcoma in the liver. A case report and a review of the literature.

We treated a 67-year-old man with primary carcinoma and sarcoma arising from the different areas of the cirrhotic liver. Histologically the carcinoma was of hepatocellular origin and the sarcoma consisted mainly of poorly differentiated mesenchymal cells partly with a chondrosarcomatous component. Among nine similar cases reported in the literature, only one was a rhabdomyosarcoma and the others were described simply as of spindle cell variety without evidence of mesenchymal differentiation.

Cytophotometric DNA analysis of mucosal and submucosal carcinoma of the esophagus.

Cell nuclear deoxyribonucleic acid (DNA) content was microspectrophotometrically determined in 35 cases of mucosal and submucosal carcinoma of the esophagus. DNA distribution pattern was classified into types I, II, III, and IV, according to the degree of dispersion on the DNA histogram, in the order of wider distribution. Patients with types I and II (relatively regular in DNA distribution) had an uneventful postoperative course and no recurrence, whereas 3 of 15 (20%), and 5 of 9 (55.

Postoperative adjuvant chemotherapy for gastric carcinoma. Analysis of data on 1805 patients followed for 5 years.

The effectiveness of combination chemotherapy with mitomycin-C (MMC) plus Futraful (N1-(2'-tetrahydrofuryl)-5-fluorouracil) for gastric cancer was investigated in a prospective randomized and controlled study. Two thousand sixty-four Japanese patients in 297 hospitals were entered, and 1805 could be followed. All patients had undergone gastrectomy from May 1975 to July 1976.

Promoter exchange between ompF and ompC, genes for osmoregulated major outer membrane proteins of Escherichia coli K-12.

Expression of the ompF and ompC genes coding for major outer membrane proteins OmpF and OmpC is regulated in opposite directions by medium osmolarity. Chimera genes were constructed by a reciprocal exchange of the promoter-signal sequence region between the two genes. The chimera gene construction was designed so that the proteins synthesized by these genes were essentially the same as the OmpC and OmpF proteins.

Hormone conditioned cancer chemotherapy for recurrent breast cancer prolongs survival.

Left suprarenal-inferior mesenteric venous shunt (Inokuchi) was prescribed for 80 patients with recurrent breast cancer and the efficacy of hormone conditioned cancer chemotherapy was assessed. The patients were separated into 3 groups according to the historical regimen of combined chemotherapy: Group I; surgical hormone therapy alone, Group II; surgery plus short term chemotherapy, and Group III; surgery plus long term chemotherapy. The 5 year survival rate of the responsive patients to the surgical hormone therapy was as high as 84.

A prospective study on primary gastric stump cancer following partial gastrectomy for benign gastroduodenal diseases.

A prospective study was made on 3827 Japanese patients who had undergone partial gastrectomy for benign gastroduodenal diseases to examine whether they are at a high risk of mortality from primary gastric stump cancer (PGSC) and whether the risk is determined by the surgical procedure. The patients were followed up from the time of surgery (from 1948 to 1970) to June 30, 1981. Of 3,701 patients (96.

Arterial hypoxemia in patients with hepatic cirrhosis.

Pulmonary function tests were studied in 105 patients with cirrhosis of the liver who had no clinical or radiographical evidence of cardiopulmonary disease. Spirometric data such as VC, FRC, RV, TLC, RV/TLC and FEV1.0% were within normal limits in all subjects.

[A case of carcinoma originating from accessory breast tissue of the axilla].

We report a case of carcinoma originating from accessory breast tissue of axilla and review 33 reported cases of carcinoma in heterotopic breast tissue. Although the incidence of accessory breast cancer is not high, early diagnosis and treatment are necessary, keeping in mind the possibility of this carcinoma when subcutaneous nodules of uncertain origin are found around the breast. Surgical treatment which must at least include wide local extirpation including the surrounding tissues and dissection of the axillary lymph nodes is necessary and adjunctive chemotherapy and irradiation appear to be useful.

Inhibition by bradykinin of renal adrenergic effects in anesthetized rats.

We studied the contribution of prostaglandins to the actions of bradykinin at the renal vascular adrenergic neuroeffector junction by examining the effect of the peptide on the decrease in renal blood flow elicited by renal nerve stimulation and injected norepinephrine in pentobarbital-anesthetized rats with or without pretreatment with the cyclooxygenase inhibitors sodium meclofenamate or indomethacin. Infusion of bradykinin, 10 ng X kg-1 X min-1, into the renal artery reduced both the basal and the rise in renal vascular resistance produced by nerve stimulation or norepinephrine. The prostaglandin precursor arachidonic acid, 5 micrograms X kg-1 X min-1, infused into the renal artery, also reduced renal vascular resistance and the vasoconstrictor response elicited by either adrenergic stimulus.

Deficient superoxide-generating activity and its activation of blood monocytes in cancer patients.

Superoxide (O2-)-generating activity of blood monocytes, the precursors of macrophages, from patients with advanced cancer and/or infection was studied. Monocytes from normal subjects generated 0.288 +/- 0.

Bidirectional effects of splenectomy on the growth of syngeneic tumor in mice.

The effects of splenectomy on tumor growth following inoculation with a relatively large number of cells (1 X 10(7) ) and a smaller number of cells (5 X 10(5) ) of Meth I tumor were studied. When 1 X 10(7) tumor cells were inoculated, tumor growth in splenectomized mice was depressed, while tumor in sham-operated mice grew progressively. On the contrary, when 5 X 10(5) tumor cells were inoculated, the tumor take was lower in sham-operated than in splenectomized mice.

Selective effects of Lipiodolized antitumor agents.

Lipiodol Ultra-Fluid (Lipiodol) remains selectively in the tumor for an extended time when applied through arteries feeding the tumor. Although lipophilic antitumor drugs are selective when combined with Lipiodol, wide application of common hydrophilic agents is limited, as these compounds are insoluble in oil. We propose "Lipiodolization" of water-soluble agents using as an intermediate Urografin, a water-soluble contrast medium.

Attenuation by prostaglandins of adrenergically induced renal vasoconstriction in anesthetized rats.

We have investigated the role of prostaglandins (PG) in the modulation of adrenergic neuroeffector events by examining the effect of PGI2 and PGE2 and their precursor, arachidonic acid, on the decrease in renal blood flow elicited by renal nerve stimulation or by injected norepinephrine in pentobarbital-anesthetized rats, with or without pretreatment with the cyclooxygenase inhibitor, sodium meclofenamate. Administration of PGI2 or PGE2 (0.4 micrograms X kg-1 X min-1) or arachidonic acid (5 micrograms X kg-1 X min-1) into the renal artery reduced vascular resistance and inhibited the vasoconstrictor response elicited by renal nerve stimulation or by injected norepinephrine.

Effect of hemorrhagic shock on pulmonary transvascular fluid and protein exchange in anesthetized dogs.

We demonstrated the effect of hemorrhagic shock with resuscitation on pulmonary fluid and protein exchange in anesthetized dogs. Lung lymph flow decreased during early shock and then increased gradually to baseline during late shock as the pulmonary vascular pressures reverted toward baseline levels, while the lymph-to-plasma protein ratio remained relatively constant throughout the shock period. During resuscitation, lung lymph flow increased significantly with the decreasing lymph:plasma protein ratio, suggesting no change in permeability to proteins.