Publications by authors named "Inne Hilbrand Max Borel Rinkes"
More than half of all patients with cancer receive radiation therapy, but resistance is commonly observed. Currently, it is unknown whether resistance to radiation therapy is acquired or inherently present. Here, we employed organoids derived from rectal cancer and single-cell whole-genome sequencing to investigate the long-term evolution of subclones in response to radiation.
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- Radiation lobectomy is a treatment that uses targeted radiation to help shrink liver tumors and grow healthy liver tissue.
- In a study, researchers looked at patients with colorectal liver cancer and found that the amount of radiation didn't clearly affect the tumor's response.
- They discovered that tumors with certain markers, like higher levels of a growth marker (Ki-67) and cancer stem cells (Olfm4), were less likely to shrink, highlighting that some cancer cells are tough and need quick surgery after radiation treatment.