A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum.

A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

Novel matrix metallo-proteinase (MMP-2) phosphonoboronate inhibitors.

A series of novel phosphonoboronates consisting of PC(1)B, PC(n)B, PC(X)C(n)B, and PCC=CB derivatives were evaluated as MMP-2 inhibitors. Structure-activity relationships (SARs) data for the compounds were discovered and are discussed.