Effect of Interferon Inducer Neovir on the Sensitivity MDR1(-) and MDR1(+) Cells to Antitumor Drugs.

The ability of synthetic interferon inducer, neovir (sodium 10-methylencarboxylate-9-acridone), was studied dealing with modulation of the sensitivity of HT-29 and K-562 cells, intact and transfected with mdr1 gene, in relation to the cytototoxic action of antitumor drugs. Neovir exerted the direct cytotoxic action on cells of all studied lines. Preliminary incubation of cells with neovir for 24 h efficiently increased the cytotoxic effect of doxorubicin and vincristine.