Publications by authors named "Inklisan Patel"
Article Synopsis
- Fisetin shows potential as a treatment for epilepsy but has issues like poor solubility and quick breakdown that affect its effectiveness.
- The study tested fisetin loaded in chitosan nanoparticles (NP) on mice with epilepsy to see if it could improve its anticonvulsant properties.
- Results indicated that fisetin NP provided protection against seizures and behavior issues, possibly by reducing oxidative stress and inflammation in the brain, suggesting a new potential therapy for epilepsy.
Aim: Pancreastatin, a dysglycemic hormone that encourages inflammation and steatosis in a variety of metabolic disorder animal models. The purpose of this study is to determine the effect of the pancreastatin inhibitor PSTi8 on immunometabolic changes in the liver of MCD-induced NASH mice.
Main Methods: Methionine and choline-deficient (MCD) diet was used for the development of NASH.
Aims: Pancreastatin (PST), an anti-insulin peptide derived from chromogranin A. Its levels increase in cases of obesity, which contributes to adipose tissue inflammation and insulin resistance. This study aims to investigate the immunometabolic effect of PST inhibitor (PSTi8) against PST by using in vitro and in vivo finding.
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