[TRACING THE PHARMACY OF KARLOVAC: CHRONOLOGY OF THE FIRST PHARMACY “TO THE BLACK EAGLE”].

“The Black Eagle” pharmacy in Karlovac was founded in 1726 as the sixth military pharmacy in Croatia, and it has been continuously operating until today. In this work, relying on available literature, archival sources, and information from contemporary publications, the complete reconstruction of the historical continuity and ownership sequence of the oldest pharmacy in Karlovac is presented for the first time. All pharmacists who have made their mark in the operation of the pharmacy are listed, and biographies of those pharmacists who had a special significance in Karlovac’s pharmacy and social life of that time are highlighted.

Mendeleev's discovery of the periodic table and the first European Academy of Sciences to honour him.

The chemical science community will commemorate the 155 anniversary of Mendeleev's groundbreaking discovery of the periodic table of elements in 2024. This paper aims to underscore the significance of Mendeleev's honorary membership in the Academy of Sciences in Zagreb, Croatia, which occurred in 1882, making it the first scientific academy in Europe to extend this recognition. Additionally, we seek to explore the contextual circumstances that contributed to this noteworthy event within the broader European context.

The Croatian Translation of : From Health Instructions with Medicinal Plants to Contemporary Phytotherapy.

Medieval European medicine relied on monasteries where ancient medical works were transcribed. Trade routes to the East and the influence of Arab medicine, which supplemented the knowledge of Greco-Roman physicians, enabled the foundation and development of the Salerno Medical School, whose most famous work is This medical textbook, written in verse and drawn up on the basis of ancient sources and empirical experiences of Salerno physicians, contains rules on how to preserve health, on diseases and the use of medicinal plants for medicinal purposes. The work was originally written in Latin, and was translated into Croatian by Franciscan Father Emerik Pavi (1768).

Hydroxypropyl-β-Cyclodextrin-Based Extracts: Antioxidant and Cosmeceutical Activity and Biocompatibility.

Two extracts, OPT-1 (rich in phenolic acids) and OPT-2 (rich in total phenols and flavonoids), were prepared using hydroxypropyl-β-cyclodextrin (HP-β-CD)-assisted extraction. The prepared extracts were rich in phenolic compounds, including flavonoids and phenolic acids. GC-MS analysis of the extracts identified neryl acetate, neo-intermedeol, β-selinene, γ-curcumene, italidione I, and nerol as the main volatile components of the extracts, as well as plant sterols, γ-sitosterol, campesterol, and stigmasterol.

Optimization of Cyclodextrin-Assisted Extraction of Phenolics from for Preparation of Extracts with Anti-Elastase and Anti-Collagenase Properties.

is a plant traditionally used for skin-related disorders that is becoming an increasingly popular ingredient in cosmetic products. In this work, a "green" ultrasound-assisted extraction method for phenolics was developed using skin-friendly cyclodextrins (CDs). Extraction conditions needed for the greatest yield of target compounds (total phenolics, phenolic acids, and flavonoids) were calculated.

Overview of Dioscorides' recipes in Croatian books of folk recipes.

The aim of this paper is to present an overview of Dioscorides' recipes from his work which are found in Croatian folk medicine preserved in books of folk recipes called . The particularities of five published and analysed Croatian books of folk recipes from the 17 th and 18 th century are examined. Recipes with drugs of herbal and animal origin, which are most often mentioned in Croatian books of folk recipes, and which were available in folk medicine at the time, are compared with those from Dioscorides' work.

Minocycline as heart conditioning agent in experimental type 2 diabetes mellitus - an antibacterial drug in heart protection.

Cardiovascular diseases, and among them certainly myocardial infarction, remain leading cause of death worldwide. Diabetes increases risk of occurrence as well as adverse outcome of myocardial infarction. Conditioning maneuvers are the most attractive method for alleviating both the consequences of ischemia and reperfusion.

The Effect of Ultrasonic Treatment on the Binding of the Inclusion Complex β-Cyclodextrin-peppermint Oil with Cellulose Material.

The purpose of the research was to measure the increase in the binding of inclusion complexes β-cyclodextrin-peppermint oil (β-CD_PM) to cellulose in cotton and cotton/polyester material with BTCA as the crosslinking agent by applying an ultrasonic bath at room temperature and a frequency of 80 kHz for 10 min. After sonication, the samples were left in a bath for 24 h after which they were dried, thermocondensed and subjected to a number of wash cycles. The treated samples were analysed with Attenuated total reflection (ATR) units heated up to 300 °C (Golden Gate (FTIR-ATR)) to monitor chemical changes indicative of crosslinking, while physico-chemical changes in the samples were monitored by using Fourier transform infrared spectroscopy (FTIR-ATR).

Adolf Thierry and the first pharmaceutical factory in Southeast Europe.

The paper explores the beginnings of pharmaceutical industry development in Croatia and the establishment of the first pharmaceutical factory in Southeast Europe. Adolf Thierry de Chateauvieux (St. Pölten, 1854 - Pregrada, 1920), a nobleman hailing from France, immigrated to Croatia at the end of the 19 th century.

Critical evaluation of the use of total reflection X-ray fluorescence spectrometry for the analysis of whole blood samples: application to patients with thyroid gland diseases.

Multielemental analysis of whole blood can provide significant information for the evaluation of nutritional status and diagnosis of certain diseases as well as for the assessment of exposure to potentially toxic metals. However, the quantification of multiple elements in whole blood is not easy partly because of the wide variation in element concentrations (from ng L to g L) and the complex matrix. The aim of this work was to develop a fast, sustainable, and reliable analytical method, in combination with low-power TXRF, for multielemental analysis of blood samples.

Level of minerals and trace elements in the urine of the participants of mountain ultra-marathon race.

The aim of the present study was to explore impact of endurance exercise on urinary level of minerals and trace elements as well as on some oxidative stress and biochemical parameters. Urine samples were collected from participants (n=21) of mountain ultra-marathon race (53km; Medvednica, Zagreb, Croatia), before (baseline value), immediately after, 12h and 24h after the race. In urine samples level of minerals (Ca, P, K and Na) and trace elements (Se, Zn, Mn, Cu, Fe and Co) were assessed using the bench top Total reflection X-ray Fluorescence (TXRF) spectrometer.

[Humanities as a means of survival: the testimony of a Siberian prisoner of war in the First World War].

This article looks into the autobiography of the Croatian chemist and pharmacognosist Antun Vrgoč (1881-1949) entitled My Memories of the World War 1914-1920 and published in Zagreb in 1937. The author was captured in October 1914 and deported to Siberia, where he remained prisoner of war until 1920. Since there are few memoirs describing the life of Siberian prisoners during the First World War, this work is a precious testimony about the attitude towards the prisoners of war, human relations, and the survival of an AustroHungarian army officer.

The history of pharmacy studies in Croatia.

The first study of pharmacy on Croatian territory was founded in the early 19th century (1806-1813). Vicencio Dandolo (1758-1819), a pharmacist from Venice who was Napoleon's governor of Dalmatia, established a lyceum in Zadar in 1806. It included education for pharmacists.

The original Croatian pharmacopoeia from 1901.

The second edition of the Croato-Slavonian Pharmacopoeia was published in Zagreb in 1901. As the original scientific work of two university professors, Gustav Janecek and Julije Domac, the Pharmacopoeia had strong scientific foundations and introduced a number of innovations. For the first time, a pharmacopoeia prescribed optical rotation for the examination of essential oils, introduced the quantitative analysis of active ingredients in galenic preparations, standardized the boiling points at the atmospheric pressure of 760 mm Hg, and was the only one to prescribe antidotes for herbal drugs and preparations which may cause poisoning.

[Manuscript "Many different remedies for headache treatment" from the archives of Sinj Friary].

Manuscripts containing collections of folk recipes for treatment of deseases were written mostly by Catholic priests especially Franciscians in Croatia in the past centuries. They were used as manuals for preparation of remedies and gave directions for their use. These writtings provide valuble data for etnographers and historians of ethnomedicine.

The first independent pharmacognosy institute in the world and its founder Julije Domac (1853-1928).

The aim of this article is to describe the foundation and development of the first distinct Institute of Pharmacognosy in the world and to provide a biography of its founder Julije Domac. The Institute was founded in 1896 as a separate institution at the University of Zagreb, Croatia, part of the Austro-Hungarian Empire at the time. In other European university centers, pharmacognosy institutes were founded together with pharmacology, botany, pharmaceutical or general chemistry.