Patients' Use of Electronic Health Records Facilitates Patient-Centered Communication: Findings From the 2017 Health Information National Trends Survey.

Background: Patient-centered communication refers to interaction between patients and health professionals that considers patients' preferences and empowers patients to contribute to their own care. Research suggests that patient-centered communication promotes patients' satisfaction with care, trust in physicians, and competence in their abilities to manage their health.

Objective: The study aims to explore the role of patients' use of electronic health records (EHRs) in promoting patient-centered communication.

What Is the Draw of the Metaverse? Personality Correlates of Zepeto Use Motives and Their Associations With Psychological Well-Being.

Despite the hype surrounding the metaverse, there is scant empirical research that examines who uses the service, for what specific purposes, and with what consequences. Based on a survey of current Zepeto users ( = 200), a popular metaverse application that enables people to create avatars and socialize while exploring the virtual spaces, we investigated (a) the key motives of Zepeto use, (b) how Big Five personality traits predict specific motives of Zepeto use, and (c) how specific motives of Zepeto use are associated with users' psychological well-being. Overall, users were largely driven by the desire to explore the virtual world and enjoy unique experiences, but such a tendency was stronger among those higher on openness and agreeableness.

ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.

Although RAF monomer inhibitors (type I.5, BRAF(V600)) are clinically approved for the treatment of BRAF-mutant melanoma, they are ineffective in non-BRAF mutant cells. Belvarafenib is a potent and selective RAF dimer (type II) inhibitor that exhibits clinical activity in patients with BRAF- and NRAS-mutant melanomas.

Preparation, characterization, and pharmacological study of a novel long-acting FGF21 with a potential therapeutic effect in obesity.

FGF21 (Fibroblast Growth Factor 21), which is expressed in the liver, adipose tissue, and pancreas, has been widely known as a therapeutic candidate for metabolic diseases. Though FGF21 is crucial to glucose, lipid, and energy homeostasis, it is not straightforward to develop a new drug with FGF21 due to its short half-life in serum. Here, we derived a novel long-acting FGF21 (LAPS-FGF21), which is chemically conjugated to the human IgG4 Fc fragment for longer half-life in serum.

Design, synthesis and biological evaluation of new bivalent quinazoline analogues as IAP antagonists.

We recently reported the biological evaluations of monovalent IAP antagonist 7 with good potency (MDA-MB-231, IC = 19 nM). In an effort to increase cellular activity and improve favorable drug-like properties, we newly designed and synthesized bivalent analogues based on quinazoline structure of 7. Optimization of cellular potency and CYP inhibition led to the identification of 27, which showed dramatic increase of over 100-fold (IC = 0.

Multiple Reaction Monitoring Mode Based Liquid Chromatography-Mass Spectrometry Method for Simultaneous Quantification of Brassinolide and Other Plant Hormones Involved in Abiotic Stresses.

Plant hormones are the key regulators of adaptive stress response. Abiotic stresses such as drought and salt are known to affect the growth and productivity of plants. It is well known that the levels of plant hormones such as zeatin (ZA), abscisic acid (ABA), salicylic acid (SA), jasmonic acid (JA), and brassinolide (BR) fluctuate upon abiotic stress exposure.