Publications by authors named "Inha Baek"
Article Synopsis
- Traumatic spinal cord injury (SCI) leads to permanent loss of movement and sensation below the injury, making effective therapies a complex challenge despite ongoing research.
- Our lab created a new therapy using human adipose-derived stem cells within hydrogels made from different ratios of decellularized sciatic nerve and spinal cord materials, aiming to promote repair.
- The study found that the composition of the hydrogels and the duration of culture influenced the release of growth factors, but different hydrogel formulations did not significantly alter certain cell behaviors, with the 1:2 ratio of nerve to spinal cord showing the most potential for further research.
Traumatic spinal cord injuries (SCI) are debilitating injuries affecting twenty-seven million people worldwide and cause functional impairments. Despite decades of research and medical advancements, current treatment options for SCI remain limited, in part due to the complex pathophysiology of spinal cord lesions including cellular transformation and extracellular matrix (ECM) remodeling. Recent studies have increased focus on fibrotic scarring after SCI, and yet much remains unclear about the impact of fibrotic scarring on SCI lesion progression.
View Article and Find Full Text PDFTraumatic spinal cord injury (SCI) induces permanent sensorimotor deficit below the site of injury. It affects approximately a quarter million people in the US, and it represents an immeasurable public health concern. Research has been conducted to provide effective therapy; however, SCI is still considered incurable due to the complex nature of the injury site.
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