Publications by authors named "Ingy El-Soudany"
Article Synopsis
- - The study explores the effects of the anti-inflammatory drug diclofenac on an opportunistic pathogen known for causing hospital infections, specifically looking at its antibacterial properties and how it can enhance the effectiveness of the antibiotic levofloxacin against resistant strains.
- - Researchers determined the minimum concentration needed to inhibit the bacteria and tested both the drug alone and in combination, finding that diclofenac significantly reduced levofloxacin resistance and decreased gene expression associated with efflux pumps and biofilm formation.
- - The results indicated that diclofenac alone could inhibit bacterial growth at a low concentration, while its combination with levofloxacin further improved its antibacterial action and reduced biofilm formation by about 40-46%, suggesting potential for overcoming antibiotic
Objective: Acinetobacter baumannii (A. baumannii) is an opportunistic bacterium with multiple virulence factors, including capsule and biofilm, and is known for its high drug resistance. Anti-virulence natural substances have been suggested as novel alternatives to conventional antibiotics.
View Article and Find Full Text PDFNanotechnology is the use of materials that have unique nanoscale properties. In recent years, nanotechnologies have shown promising results for human health, especially in cancer treatment. The self-assembly characteristic of RNA is a powerful bottom-up approach to the design and creation of nanostructures through interdisciplinary biological, chemical and physical techniques.
View Article and Find Full Text PDFBackground And Objectives: is a problematic opportunistic pathogen causing several types of nosocomial infections with a high resistance rate to antibiotics. Production of many virulence factors in is regulated by quorum sensing (QS), a cell-to-cell communication mechanism. In this study, we aimed to assess and compare the inhibitory effect of azithromycin (AZM) and EPI-PAβN (efflux pump inhibitor-Phenylalanine-Arginine Beta-Naphthylamide) on QS system and QS-dependent virulence factors in clinical isolates.
View Article and Find Full Text PDF