Hypoxia due to shunts in pig lung treated with O2 and fluorocarbon-derived intravascular microbubbles.

Rationale: Earlier work has shown that experimental conditions calling for improved tissue oxygenation could be assisted by i.v. infusion of a dodecafluoropentane emulsion (DDFPe) forming oxygen-transporting microbubbles.

Intravascular fluorocarbon-stabilized microbubbles protect against fatal anemia in rats.

It has earlier been hypothesized that intravascular microbubbles, derived from a dodecafluoropentane (DDFP) emulsion, can transport physiologically significant amounts of oxygen in the animal body. To test this notion, anesthetized oxygen breathing rats were rendered severely anemic by bleeding and volume replacement. Rats treated with 0.