Publications by authors named "Ingrid Scheidhammer"
Local anesthetic cytotoxicity on human mesenchymal stem cells during chondrogenic differentiation.
Knee Surg Sports Traumatol Arthrosc
April 2015
Article Synopsis
- The study aimed to explore how local anesthetics affect the viability of human mesenchymal stem cells (MSCs) during their development into cartilage.
- Results showed that while there was a temporary increase in cell death rates immediately following exposure to anesthetics, by day 21, the overall viability of MSCs was comparable to control groups. However, local anesthetics notably reduced Collagen II levels in the aggregates.
- In conclusion, the presence of local anesthetics has cytotoxic effects on MSCs, particularly in the outer regions, which could impact their potential in regenerative therapies.