Antipsychotic augmentation with modafinil or armodafinil for negative symptoms of schizophrenia: systematic review and meta-analysis of randomized controlled trials.

We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of modafinil or armodafinil (ar/mod) augmentation in schizophrenia. We searched PubMed, clinical trial registries, reference lists, and other sources for parallel group, placebo-controlled RCTs. Our primary outcome variable was the effect of ar/mod on negative symptom outcomes.

Investigation of the possible role of Shankapushpi in the attenuation of ECT induced amnestic deficits.

Introduction: Shankapushpi (Evolvulus alsinoides and others) has received mention in traditional Indian writings as a potential enhancer of cognitive functioning. This study used an animal model to examine whether Shankapushpi improves learning and memory and attenuates anterograde and retrograde amnesia associated with electroconvulsive shocks (ECS).

Materials And Methods: Adult, male, Sprague Dawley rats (n=64) were treated with an aqueous extract of Shankapushpi or vehicle all through the 13-day study.