Publications by authors named "Ingrid K Fosheim"
Background: Hypertensive disorders of pregnancy (preeclampsia, gestational hypertension, and chronic hypertension), diabetes mellitus, and placental dysfunction confer an increased risk of long-term maternal cardiovascular disease. Preeclampsia is also associated with acute atherosis that involves lesions of uteroplacental spiral arteries, resembling early stages of atherosclerosis. Serum amyloid A1 is involved in hypercoagulability and atherosclerosis and may aggregate into amyloid-aggregations of misfolded proteins.
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- Decidua basalis, the layer of the uterus involved in pregnancy, is crucial for maternal-fetal interaction and is linked to a condition called acute atherosis, which affects spiral arteries and is often seen in complications like preeclampsia and fetal growth restriction.
- Researchers have developed a vacuum suction method to obtain decidua basalis tissue for studying acute atherosis and how it relates to inflammation in pregnancy, since sampling this tissue has been difficult previously.
- The study suggests that various inflammatory and vascular factors contribute to acute atherosis formation, and proposes a link between fetal microchimerism in women with preeclampsia and risks of cardiovascular issues later in life.
Background: Cystic echinococcosis (CE) caused by Echinococcus granulosus, significantly impacts health globally, but is a rare disease in Norway. CE is treated with a combination of anthelmintics and surgery, or percutaneous drainage.
Case Presentation: A woman in her thirties underwent extensive surgery due to disseminated CE in the abdominal cavity and liver.
Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a successful placentation and normal placental function. It is an intricate process that involves, but is not restricted to, complex interactions between maternal decidual immune cells and invasive trophoblasts in the uterine wall. In normal pregnancy, the smooth muscle cells of the arterial tunica media of uteroplacental spiral arteries are replaced by invading trophoblasts and fibrinoid, and the arterial diameter increases 5- to 10-fold.
View Article and Find Full Text PDFIntroduction: Acute atherosis (AA) is a lesion affecting uteroplacental spiral arteries during pregnancy, most frequently in preeclampsia but occasionally in normal pregnancy. It is commonly observed in untransformed spiral arteries (intact smooth muscle cell layer, lacking intramural trophoblasts). The mechanism causing lesion development is unknown.
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