Higher Prepubertal IGF-1 Concentrations Associate to Earlier Pubertal Tempo in Both Sexes.

Introduction: Pubertal onset is triggered by multiple neuroendocrine interactions. The role of prepubertal IGF-1 in this process has not been explored in both sexes. Our objective was to analyze the association of prepubertal IGF-1 concentration with age at thelarche (B2) and menarche (M) in girls and age at gonadarche (G2) in boys.

Total and Central Adiposity Are Associated With Age at Gonadarche and Incidence of Precocious Gonadarche in Boys.

Context: A close link between body mass index (BMI) and female pubertal onset is well established. However, observations in boys remain inconclusive.

Objective: We aim to determine whether BMI as well as total and central adiposity in prepubertal Chilean boys is associated with pubertal timing.