Strength, mobility and falling in women referred to a geriatric outpatient clinic.

Background And Aims: Mobility impairment and falling have a multifactorial etiology in frail older people. Muscle weakness is one of the risk factors and is accessible to intervention. The aim of this study was to determine the most important contributors of mobility and indicators of fall occurrence in women referred to a geriatric outpatient clinic.

Muscle strength and tibolone: a randomised, double-blind, placebo-controlled trial.

Objective: To investigate the effects of tibolone, a tissue-specific compound with a mixed (estrogenic, progestogenic and androgenic) hormonal profile, on skeletal muscle strength in a group of healthy postmenopausal women.

Design: Randomised, parallel group, double-blind, placebo-controlled, single-centre trial conducted between August 1997 and July 1999.

Participants: Eighty-five healthy women, between one and 15 years postmenopausal, (mean [SD] age, 54.

Tibolone does not affect muscle power and functional ability in healthy postmenopausal women.

Maintenance of neuromuscular function into old age is critical to maintain normal daily activity and functional independence. Maximal muscle strength declines with age, and the age-related loss in power might be even greater. An accelerated loss of muscle strength and power has been observed in women around the time of the menopause.

The influence of tibolone on quality of life in postmenopausal women.

Objectives: To examine the effect of tibolone, a synthetic steroid with tissue-specific activity, on quality of life in a randomised, double-blind, placebo-controlled study in healthy postmenopausal women.

Material And Methods: A total of 85 women (54.2+/-4.