Oral HPV prevalence in women positive for cervical HPV infection and their sexual partners: a German screening study.

The incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell cancer (OSCC) is on the rise. With the HPV-positive uterine cervix as a reservoir, HPV-positive OSCC is discussed as a sexually transmitted disease. Mechanisms of HPV transmission to the oral cavity are poorly understood.

Epidemiology of laryngeal carcinoma in Germany, 1998-2011.

Constituting 25-30 % of all head and neck cancer cases, laryngeal carcinoma is the most prevalent entity. Major risk factors of laryngeal cancer are smoking and excessive alcohol consumption. This study presents the recent developments in the incidence of laryngeal cancer from 1998 to 2011 in Germany.

Intensity modulated perioperative HDR brachytherapy for recurrent and/or advanced head and neck metastases.

Recurrent neck metastases following surgery and full dose adjuvant radiotherapy of squamous cell head and neck cancer remain a clinical challenge. After revision neck dissection and chemotherapy re-irradiation dosage is often limited and survival prognosis deteriorates. Here, adjuvant high-dose rate intensity modulated perioperative brachytherapy (HDR IMBT) offers a second full radiation dose with a limited volume of normal tissue radiation in the neck.

Perioperative image-adapted brachytherapy for the treatment of paranasal sinus and nasal cavity malignancies.

Purpose: Sinonasal malignancies are a rare group of cancers often associated with late presentation and poor prognosis. In the past, there was little progress regarding survival rate, and often, multimodal treatment regimens are required. The aim of this study was to evaluate the clinical outcome of perioperative image-adapted brachytherapy (IABT) as part of a multidisciplinary treatment regimen for the therapy of sinonasal cancer.

Nanosecond laser pulse stimulation of the inner ear-a wavelength study.

Optical stimulation of the inner ear, the cochlea, is discussed as a possible alternative to conventional cochlear implants with the hypothetical improvement of dynamic range and frequency resolution. In this study nanosecond-pulsed optical stimulation of the hearing and non-hearing inner ear is investigated in vivo over a wide range of optical wavelengths and at different beam delivery locations. Seven anaesthetized guinea pigs were optically stimulated before and after neomycin induced destruction of hair cells.

Acoustic events and "optophonic" cochlear responses induced by pulsed near-infrared laser.

Optical stimulation of neural tissue within the cochlea was described as a possible alternative to electrical stimulation. Most optical stimulation was performed with pulsed lasers operating with near-infrared (NIR) light and in thermal confinement. Under these conditions, the coexistence of laser-induced optoacoustic stimulation of the cochlea ("optophony") has not been analyzed yet.

Optical stimulation of the facial nerve: a new monitoring technique?

Objectives/ Hypothesis: One sequela of skull base surgery is iatrogenic damage to cranial nerves, which can be prevented if the nerve is identified. Devices that stimulate nerves with electric current assist in nerve identification. Contemporary devices have two main limitations: 1) the physical contact of the stimulating electrode and (2) the spread of the current through the tissue.

The hemicochlea preparation of the guinea pig and other mammalian cochleae.

The hemicochlea and its slice preparation is a novel method that allows access to various cochlear structures without the physical distortion that typically occurs from tissue dehydration during the embedding process. Therefore, the hemicochlea preparation provides an excellent model to study (1) cochlear morphology during cochlear development, (2) malformation caused by genetic defects, (3) changes related to diseases, (4) sensory physiology, (5) cochlear micromechanics, and (6) the expression of proteins by immunohistochemistry. This paper describes in detail the method of slicing hemicochleae for different mammalian species, including mice, rats, gerbils, guinea pigs, pigs, and human temporal bones.