Revisiting the Longitudinal 90° Limit in High Intensity Linear Accelerators.

Parametric envelope and sum envelope resonances are analyzed to revisit the validity of an assumed stop band and design limit of high intensity linear accelerators at a longitudinal phase advance of 90° per focusing lattice period. While the 90° limit is unquestioned in the transverse plane, we show here that it can be dropped as longitudinal limit for lattices with two or more rf gaps per focusing period. A new limit arises, however, from a novel transverse-longitudinal parametric sum envelope instability.

Space-Charge Structural Instabilities and Resonances in High-Intensity Beams.

The existence of a structural resonance stop band caused by space charge in high-current beams, where the resonance frequency is associated with 90° phase advance per focusing period, is well known and alternatively referred to in the literature as envelope instability or as fourth-order resonance. We show, however, that this stop band is actually a coincidence of a structural fourth-order resonance and the much stronger envelope instability as competing mechanisms--depending on the time scale and initial matching. A similar complexity of behavior--dependent on the distribution function--is also found between a third-order instability and a sixth-order resonance in a 60° stop band.

Cellulose-based scaffold materials for cartilage tissue engineering.

Non-woven cellulose II fabrics were used as scaffolds for in vitro cartilage tissue engineering. The scaffolds were activated in a saturated Ca(OH)(2) solution and subsequently coated with a calcium phosphate layer precipitated from a supersaturated physiological solution. Chondrocyte cell response and cartilage development were investigated.

Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis.

The SU(VAR)3-9 protein family was first identified in animals as heterochromatin-associated proteins and found to control establishment of heterochromatic chromatin domains by histone H3 lysine 9 methylation. In Arabidopsis ten SU(VAR)3-9 homologous SUVH genes are found where SUVH1, SUVH2 and SUVH4 represent different subgroups of genes. Also the SUVH1, SUVH2 and SUVH4 proteins represent heterochromatin-associated proteins and display differential effects on control of heterochromatic histone methylation marks.

Longitudinal impedance and shielding effectiveness of a resistive beam pipe for arbitrary energy and frequency.

The longitudinal coupling impedance of a cylindrical beam pipe for arbitrary relativistic gamma(0) and mode frequency is obtained analytically for finite wall conductivity and finite wall thickness. Closed form expressions for the electromagnetic fields excited by a beam perturbation are derived analytically. General expressions for the resistive-wall impedance in the presence of a metallic shield and for the rf shielding effectiveness of the beam pipe have been obtained and then compared with approximate expressions.

Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis.

SU(VAR)3-9 like histone methyltransferases control heterochromatic domains in eukaryotes. In Arabidopsis, 10 SUVH genes encode SU(VAR)3-9 homologues where SUVH1, SUVH2 and SUVH4 (KRYPTONITE) represent distinct subgroups of SUVH genes. Loss of SUVH1 and SUVH4 causes weak reduction of heterochromatic histone H3K9 dimethylation, whereas in SUVH2 null plants mono- and dimethyl H3K9, mono- and dimethyl H3K27, and monomethyl H4K20, the histone methylation marks of Arabidopsis heterochromatin are significantly reduced.

Space-charge driven emittance growth in a 3D mismatched anisotropic beam.

We investigate the phenomenon of space-charge driven emittance growth in a three-dimensional mismatched anisotropic charged particle beam with relevance to high-intensity linear accelerators. The final emittance growth can be understood as a superposition of the contributions from the mismatch-induced halo formation and from the anisotropy-induced energy exchange. The averaged emittance growth per degree of freedom is bounded from above by the so-called "free energy limit" extended by the contributions from energy exchange.

BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis.

DNA repair associated with DNA replication is important for the conservation of genomic sequence information, whereas reconstitution of chromatin after replication sustains epigenetic information. We have isolated and characterized mutations in the BRU1 gene of Arabidopsis that suggest a novel link between these underlying maintenance mechanisms. Bru1 plants are highly sensitive to genotoxic stress and show stochastic release of transcriptional gene silencing.