Publications by authors named "Ingo Andus"
Article Synopsis
- Robust cancer cell models, especially patient-derived models, are crucial for effective drug development and precision oncology research, as they maintain more genetic and phenotypic similarities to original tumors compared to conventional lines.
- Three distinct patient-derived cell lines (PDCs) representing different types of non-small cell lung cancer (NSCLC) were created and thoroughly analyzed for their characteristics, including growth patterns, genetic makeup, and responses to standard chemotherapy treatments.
- The established PDC models preserved the genetic and molecular traits of the original tumors, showed key mutations, and did not exhibit pre-existing resistance to therapies, indicating their potential usefulness in cancer research and treatment development.
In cases of cerebrospinal fluid (CSF) leaks, reliable detection of their origins is needed to seal the leak sufficiently and prevent complications, such as meningitis. A method is presented here using intrathecal administered fluorescein in a clinical case of bilateral congenital ear malformation. A fluorescent dye is administered intrathecally to achieve intraoperative visualization of CSF leaks.
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