Blinatumomab for First-Line Treatment of Children and Young Persons With B-ALL.

Purpose: We tested whether blinatumomab (Blina) is effective as a toxicity-sparing alternative to first-line intensive chemotherapy in children and young persons (CYP) with B-ALL who were chemotherapy-intolerant or chemotherapy-resistant.

Methods: Data were collected for consecutive CYP (age 1-24 years) with Philadelphia chromosome-positive or Philadelphia chromosome-negative B-ALL who received Blina as first-line therapy. Blina was given as replacement for postremission intensive chemotherapy to patients with chemotherapy intolerance or resistance.

Diverse environmental bacteria displaying activity against , the cause of soybean rust.

The management of soybean rust (SBR) caused by the obligate fungus mostly relies on the use of synthetic fungicides, especially in areas where the disease inflicts serious yield losses. The reliance on synthetic fungicides to manage this disease has resulted in resistance of populations to most fungicides. In this study, bacteria isolated from diverse environments were evaluated for their biocontrol potential against using soybean detached-leaf method and on-plant in the growth chamber, greenhouse, and field.

Paediatric inflammatory multisystem syndrome: temporally associated with SARS-CoV-2 (PIMS-TS) - A mimic of intra-abdominal malignancy.

We report the case of a school-aged boy who presented with clinical features suggesting acute appendicitis. However, further imaging which included CT, demonstrated an inflammatory mass involving the transverse colon raising the suspicion of lymphoma. He then developed intestinal obstruction, and in view of the rapid progression of the disease, he was thought to have non-Hodgkin's lymphoma.

Tau Aggregation Inducer Molecules Influence the Effects of Mutations on Aggregation Dynamics.

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) affect 6 million Americans, and they are projected to have an estimated health care cost of $355 billion for 2021. A histopathological hallmark of AD and many ADRDs is the aberrant intracellular accumulation of the microtubule-associated protein tau. These neurodegenerative disorders that contain tau aggregates are collectively known as tauopathies, and recent structural studies have shown that different tauopathies are characterized by different "strains" of tau filaments.

Assessment of ethanol autoxidation as a drop-in kerosene and surrogates blend with a new modelling approach.

Bioethanol has been considered as a more sustainable alternative for fossil fuels, and it has been used as a drop-in fuel mixture. In this paper, the autoxidation properties of real kerosene as well as single, binary and ternary surrogates with the presence of ethanol are investigated for the first time. A simplified python code is proposed to predict the pressure drop of the PetroOXY method that was used for assessing the fuel autoxidation properties.

Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition.

The microtubule-associated protein tau promotes the stabilization of the axonal cytoskeleton in neurons. In several neurodegenerative diseases, such as Alzheimer's disease, tau has been found to dissociate from microtubules, leading to the formation of pathological aggregates that display an amyloid fibril-like structure. Recent structural studies have shown that the tau filaments isolated from different neurodegenerative disorders have structurally distinct fibril cores that are specific to the disease.

Rationale and design of an evidence-based tool to guide preoperative evaluation and management.

Background: In the United States, over-testing and over-treatment are recognised causes of excess cost and patient harm. Healthcare value, defined as health outcomes achieved relative to the costs of care, has become a focus to improve the quality and affordability of healthcare.

Aim: To describe the rationale for, and development of a standardised clinical preoperative decision-support tool.

Renewable energy production and demand dataset for the energy system of Colombia.

During the last decades, an increasing number of studies have focused their attention on the development of energy system models in order to facilitate sustainable energy planning strategies and understand the technical challenges associated with the integration of renewable energy sources. However, these models usually require detailed and large amount of data as inputs. The data presented in this article provides key inputs and modelling assumptions adopted in the research paper titled "Large scale integration of renewable energy sources (RES) in the future Colombian energy system" [1].

Estimation of the Thermochemical Radii and Ionic Volumes of Complex Ions.

The estimation of the thermochemical radius is very important because most of the properties of the electrolyte solutions are, to some extent, linked to this property. Also, these thermochemical radii can be used to estimate lattice energies, which can be a very important parameter to be evaluated when assessing the possibility of synthesizing new inorganic materials. This study presents a formulation for estimating the thermochemical radii of complex ions.

Assessment and parameter identification of simplified models to describe the kinetics of semi-continuous biomethane production from anaerobic digestion of green and food waste.

Biochemical reactions occurring during anaerobic digestion have been modelled using reaction kinetic equations such as first-order, Contois and Monod which are then combined to form mechanistic models. This work considers models which include between one and three biochemical reactions to investigate if the choice of the reaction rate equation, complexity of the model structure as well as the inclusion of inhibition plays a key role in the ability of the model to describe the methane production from the semi-continuous anaerobic digestion of green waste (GW) and food waste (FW). A parameter estimation method was used to investigate the most important phenomena influencing the biogas production process.

Computational fluid dynamic modelling of the effect of ventilation mode and tracheal tube position on air flow in the large airways.

We have used computational fluid dynamic modelling to study the effects of tracheal tube size and position on regional gas flow in the large airways. Using a three-dimensional mathematical model, we simulated flow with and without a tracheal tube, replicating both physiological and artificial breathing. Ventilation through a tracheal tube increased proportional flow to the left lung from 39.

Modelling and optimisation of the operation of a radiant warmer.

This paper presents numerical calculations of the temperature field obtained for the case of a neonate placed under a radiant warmer. The results of the simulations show a very non-uniform temperature distribution on the skin of the neonate, which may cause increased evaporation leading to severe dehydration. For this reason, we propose some modifications on the geometry and operation of the radiant warmer, in order to make the temperature distribution more uniform and prevent the high temperature gradients observed on the surface of the neonate.

Simple detection of germline microsatellite instability for diagnosis of constitutional mismatch repair cancer syndrome.

Heterozygous mutations in DNA mismatch repair (MMR) genes result in predisposition to colorectal cancer (hereditary nonpolyposis colorectal cancer or Lynch syndrome). Patients with biallelic mutations in these genes, however, present earlier, with constitutional mismatch repair deficiency cancer syndrome (CMMRD), which is characterized by a spectrum of rare childhood malignancies and café-au-lait skin patches. The hallmark of MMR deficiency, microsatellite instability (MSI), is readily detectable in tumor DNA in Lynch syndrome, but is also present in constitutional DNA of CMMRD patients.

The effect of pain on training-induced plasticity of the corticomotor system.

Unlabelled: Pain is thought to interfere with training-induced plasticity of corticomotor pathways. Although this implies direct interference with plastic processes, it may be explained by compromised performance in the training task during pain. Repeated finger movements can induce plasticity and change the amplitude/direction of acceleration of finger movement evoked by transcranial magnetic stimulation (TMS).

An overview of recent applications of computational modelling in neonatology.

This paper reviews some of our recent applications of computational fluid dynamics (CFD) to model heat and mass transfer problems in neonatology and investigates the major heat and mass-transfer mechanisms taking place in medical devices, such as incubators, radiant warmers and oxygen hoods. It is shown that CFD simulations are very flexible tools that can take into account all modes of heat transfer in assisting neonatal care and improving the design of medical devices.

Heat and mass transfer under an infant radiant warmer--development of a numerical model.

The main objectives of this paper are to present a procedure of how to create and set up a model for the physical processes that take place within an infant radiant warmer and to validate that Computational Fluid Dynamics (CFD) can be used to resolve such problems. In this study, the results are obtained for a simplified model, both in terms of the geometry employed and the prescribed boundary conditions. The results were numerically verified in terms of the convergence history, monitor data and the physical correctness.

Osteoporosis and hypogonadism in men.

It is estimated that almost 1 in 10 men will suffer a fracture caused by osteoporosis after the age of 50 years. Among those are a considerable number of men who will fracture their hip. A number of therapies have demonstrated efficacy in improving bone density in men, and the issue of which therapy and when to institute it is addressed in this article.

The study of transgene copy number and organization.

The development of efficient crop transformation systems has necessitated the development of efficient methods for detailed molecular characterization of putative events. This chapter details the routine use of quantitative real-time polymerase chain reaction to determine transgene copy number in putative transgenic events. This approach has allowed the analysis of plantlets in tissue culture prior to transfer to soil and greenhouse.

Quantitative real-time PCR assay for determining transgene copy number in transformed plants.

The development of transgenic events can be limited by many factors. These include expression levels, insert stability and inheritance, and the identification of simple insertion events. All of the factors can be related to the copy number of the transgene.

Not the usual cause of superior vena cava obstruction.

Superior vena cava obstruction has a classical association with bronchial carcinoma. In the presence of cortisol excess, the diagnosis of small-cell carcinoma and ectopic ACTH production seems likely. We present a case where the clinical features did not accurately reflect the underlying pathology.

An analytical, numerical, and experimental comparison of the fluid velocity in the vicinity of an open tank with one and two lateral exhaust slot hoods and a uniform crossdraft.

The objective of this research was to compare mathematical models of the fluid velocity in the vicinity of an open tank with lateral slot exhaust. Two approaches were explored: a numerical solution assuming turbulent flow and an analytical solution assuming potential flow. A numerical simulation of the flow field in and around an open surface tank was performed using the commercial software FLUENT.

Theoretical and numerical predictions of two-dimensional Aaberg slot exhaust hoods.

Theoretical and computational fluid dynamical techniques are employed to predict the two-dimensional turbulent air flows which are created by an Aaberg slot exhaust hood, which is reinforced by a two-dimensional wall jet flow. The aim of the two-dimensional model is to numerically reveal the characteristics of the air flow in the central plane of the Aaberg workbench. A further development of the potential model is through the inclusion of the finite slot.