Publications by authors named "Inger Mechlenburg"

Background And Purpose:  Return to work (RTW) following primary total hip arthroplasty (THA) is important for patients and society. We aimed to investigate the association between markers of socioeconomic status (SES) and RTW after primary THA, and whether the association is influenced by sex, age, and comorbidity.

Methods:  Using Danish population-based registries we included 9,431 patients aged 18 to 59 years, undergoing primary THA for osteoarthritis from 2008-2018.

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Background: Muscle power is an important physical capability across all age groups and health statuses. Typically, assessing lower limb muscle power requires expensive and sophisticated equipment to ensure reliability and validity of power. Hence, there exists a clear need to identify a simple and effective functional performance test that can serve as a proxy for evaluating muscle power when equipment is unavailable.

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Background: Minimal important change (MIC) is the smallest change that can be considered important. In hip osteoarthritis (OA) several measurement instruments are recommended but lack MIC estimates.

Objectives: The objective was to estimate the MIC after supervised group-based exercise for the following measurement instruments; Hip Disability and Osteoarthritis Outcome Score (HOOS), European Quality of Life 5 Dimensions (EQ-5D-5L), 30-s Chair Stand Test, 40-m Fast-paced Walk Test, 9-step Stair Climb Test, Nottingham Leg Extension Power Rig, and unilateral One-Repetition-Maximum Leg Press.

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Introduction: The Minimal Important Change (MIC) for patient-reported outcome measures is the value that describes the smallest improvement considered worthwhile by patients. To the best of our knowledge, no MIC of the Western Ontario Osteoarthritis of the Shoulder Index (WOOS) score or the Disabilities of the Arm Shoulder and Hand (DASH) has been reported using the anchor-based predictive modeling approach based on patients with glenohumeral osteoarthritis or rotator cuff tear arthropathy. The aim of this study was to determine the MIC for WOOS and DASH in a cohort of patients with glenohumeral osteoarthritis or rotator cuff tear arthropathy treated with a total shoulder arthroplasty.

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Introduction: Acute exacerbations of COPD (AECOPD) often involve mucus hypersecretion. Thus, management of sputum retention is critical. However, the use of airway clearance techniques (ACTs) in people with AECOPD across different healthcare settings and factors influencing their selection remain unclear.

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Traditionally, patients with a fracture of the distal radius are treated in a cast if they do not require surgery. If the fracture requires manipulation, the cast is moulded to hold the reduction and maintain normal anatomical alignment during healing. However, is a cast necessary for patients whose fracture does not require manipulation? Removable splints are an alternative treatment option.

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Background: Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking regarding comparison of the effectiveness of this procedure with that of nonsurgical treatment such as resistance training.

Methods: We conducted a multicenter, randomized, controlled trial to compare total hip replacement with resistance training in patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery. The primary outcome was the change in patient-reported hip pain and function from baseline to 6 months after the initiation of treatment, assessed with the use of the Oxford Hip Score (range, 0 to 48, with higher scores indicating less pain and better function).

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Article Synopsis
  • The study investigated the impact of an 8-week preoperative low-load blood flow restricted resistance training (BFR-RT) program on knee osteoarthritis (OA) patients scheduled for total knee arthroplasty (TKA) compared to conventional care with no exercise.
  • Results showed no significant differences in physical function or patient-reported outcomes between the BFR-RT and the usual care group at 3 and 12 months post-surgery.
  • However, BFR-RT led to notable improvements in lower limb strength at 3 months postoperatively, indicating that it may enhance muscle strength but not necessarily overall physical function post-TKA.
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Objective: To investigate associations between changes in leg extensor muscle power of the affected limb (ΔLEP) and changes in physical function after 12 weeks of progressive resistance training (PRT) or neuromuscular exercise (NEMEX) in patients with hip osteoarthritis.

Design: Secondary analyses of a randomized controlled trial. From 160 participants enrolled in the clinical trial and cluster randomized to PRT (n ​= ​82) or NEMEX (n ​= ​78), a total of 147 (92%) had complete follow-up data and were included in the analyses.

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Article Synopsis
  • Blood flow restriction exercise (BFRE) has the potential to help maintain muscle function after an Achilles tendon injury but lacks evidence from rigorous trials regarding its safety and effectiveness.
  • This study aims to compare the benefits of starting BFRE early (1-12 weeks) versus later (13-24 weeks) in rehabilitation for patients who have acute Achilles tendon ruptures.
  • The trial is a randomized controlled study that evaluates patient outcomes through specific tests at 13 and 25 weeks to determine if early BFRE improves recovery compared to conventional care and late BFRE.
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Introduction: Systemic sclerosis (SSc) is a rare connective tissue disease causing pain, reduced mobility and decreased health-related quality of life (HRQoL). Studies suggest that exercise is a necessary adjunct to the medical treatment.

Purpose: To examine the feasibility of a 12-week home-based exercise program for SSc patients, and evaluate changes in physical function, HRQoL and SSc-related symptoms.

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Objective: This study seeks to assess the reliability and construct validity of the 1-minute sit-to-stand test as an efficient tool for evaluating the functional capacity of individuals with systemic sclerosis, considering its time and space effectiveness.

Methods: This cross-sectional study recruited forty-nine individuals with systemic sclerosis from a university hospital in Denmark. The 1-minute sit-to-stand test was conducted twice on the same day, with an interval of approximately 10 to 15 minutes between administrations, followed by a single administration of the 6-minute walk test.

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Introduction: Guidelines have been proposed for post-operative rehabilitation following periacetabular osteotomy (PAO). However, the perspectives of individuals undergoing PAO have not been considered.

Aim: The present study aimed to explore the perceived challenges of everyday life and hopes for and expectations of post-PAO rehabilitation from the perspective of individuals with acetabular dysplasia living in Denmark and Australia.

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Introduction: Femoroacetabular impingement syndrome (FAIS) is a motion-related and position-related clinical condition of the hip associated with pain, reduced physical function and hip-related quality of life (QoL). Interestingly, higher maximal muscle strength is associated with less pain, better physical function and improved QoL in people with FAIS. Furthermore, preliminary evidence suggests that a proportion of patients with FAIS respond positively to strength exercise as first-line treatment.

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Background: Limited evidence exists regarding the effectiveness of pain relief and functional improvement in patients undergoing revision total hip replacement (THR). Furthermore, there are no clinical guidelines or consensus on optimal rehabilitation after revision THR.

Purpose: The primary aim of this study was to compare the effectiveness of an exercise intervention targeting hip strengthening with standard community-based rehabilitation in patients undergoing revision THR.

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Background And Purpose: Few studies have examined the impact of comorbidity on functional and clinical knee scores after primary total knee arthroplasty (TKA). We compared the effect of having a high Charlson Comorbidity Index (CCI), relative to a low CCI, on changes in the American Knee Society Score (AKSS) functional and clinical scores from baseline to week 52 after TKA in patients with knee osteoarthritis (OA).

Methods: This population-based cohort study included 22,533 patients identified in the Danish Knee Arthroplasty Register from 1997 to 2021.

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Background And Purpose: We aimed to examine the association between socioeconomic status (SES) markers and opioid use after primary total hip arthroplasty (THA) due to osteoarthritis, and whether sex, age, or comorbidities modify any association.

Methods: Using Danish databases, we included 80,038 patients undergoing primary THA (2001-2018). We calculated prevalences and prevalence ratios (PRs with 95% confidence intervals [CIs]) of immediate post-THA opioid use (≥ 1 prescription within 1 month) and continued opioid use (≥ 1 prescription in 1-12 months) among immediate opioid users.

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Objectives: The aim of this study was to identify prognostic variables at baseline associated with being responding favorably to multidisciplinary rehabilitation in patients with chronic low back pain (CLBP).

Methods: A responder analysis was conducted based on data from a randomized controlled trial with 26-week follow-up including 165 patients with CLBP treated at a Danish multidisciplinary rehabilitation center. Patients were dichotomized into responders and non-responders based on the outcome of a minimal clinically important difference of six points on the Oswestry Disability Index.

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The dysplastic hip is characterized by incomplete coverage of the femoral head, resulting in increased risk of early osteoarthritis. The morphological variation of the hip joint is diverse and clear differences exist between females and males. The aim of this observational study was therefore to investigate the relationship between the morphology of the hip, sex, and hip dysplasia using a three-dimensional model.

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Blood flow restriction exercise (BFRE) appears to provide a unique opportunity to preserve lower limb muscle and function in patients with an Achilles tendon rupture. The purpose of this study was to investigate the feasibility of BFRE in patients with an Achilles tendon rupture. Additionally, to evaluate muscle volume and patient-reported ankle function, symptoms, complications, and physical activity following 12 weeks of BFRE.

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Purpose: After anterior cruciate ligament reconstruction (ACL-R), a localised scar tissue called cyclops lesion may develop anterior to the graft causing knee extension deficits, pain, oedema, clicking and reduced knee function. This study determined the incidence of arthroscopic resection of a cyclops lesion within 2 years after ACL-R and investigated the associations of patient characteristics and surgical techniques with the need for arthroscopic resection of a cyclops lesion.

Methods: This study included patients who underwent primary ACL-R with adult surgical technique from 2005 to 2019 at Aarhus University Hospital, Denmark.

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Background: Exercise is recommended as first-line treatment for patients with hip osteoarthritis (OA). However, randomized controlled trials providing evidence for the optimal exercise type are lacking.

Objective: To investigate whether progressive resistance training (PRT) is superior to neuromuscular exercise (NEMEX) for improving functional performance in patients with hip OA.

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Background: Proximal humerus fracture (PHF) is a common fragility fracture in older adults and can have a substantial impact on upper limb function. Although most patients with PHF can be treated nonsurgically, it is unknown whether older adults benefit from supervised exercise therapy after PHF. Therefore, the objective of this trial was to investigate whether 10 weeks of physiotherapist-supervised exercises once a week were superior to 10 weeks of unsupervised home-based exercises in older adults with a nonsurgically treated displaced 2-part PHF.

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Objectives: To estimate the effectiveness of exercise at end of treatment and long-term follow-up compared to a control condition or other conservative treatments in patients with Greater Trochanteric Pain Syndrome (GTPS).

Methods: Databases were searched September 2021 and updated September 2023. Randomized controlled trials (RCT) comparing exercise interventions for patients with GTPS, to a control condition; corticosteroid injection; shock wave therapy; or other types of exercise programs were included.

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