Publications by authors named "Ingebjoerg Lien"

Background: Since 2023, ChatGPT-4 has been impactful across several sectors including healthcare, where it aids in medical information analysis and education. Electronic patient-reported outcomes (ePROs) play a crucial role in monitoring cancer patients' post-treatment symptoms, enabling early interventions. However, managing the voluminous ePRO data presents significant challenges.

View Article and Find Full Text PDF

Background: Aging in older adults results in a decline in physical function and quality of daily life. Due to the COVID-19 pandemic, the exercise frequency among older adults decreased, further contributing to frailty. Traditional rehabilitation using repetitive movements tends not to attract older adults to perform independently.

View Article and Find Full Text PDF

Obesity and type 2 diabetes mellitus (T2DM) are chronic diseases with increasing prevalence, underscoring the urgent need for effective treatment and management strategies. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as an essential class of drugs for managing both obesity and T2DM, offering additional benefits for cardiovascular and kidney health. GLP-1 RAs work by targeting GLP-1 receptors, mimicking the effects of the natural hormone GLP-1 to regulate blood glucose levels, promote weight loss, and provide potential benefits for cardiovascular health.

View Article and Find Full Text PDF

High-energy metal deposition significantly impacts the performance and reliability of two-dimensional (2D) semiconductors and nanodevices. This study investigates the localized annealing effect in atomically thin InO induced during high-energy metal deposition. The localized heating effect alters the electronic performance of InO devices, especially in shorter channel devices, where heat dissipation is further constrained.

View Article and Find Full Text PDF

Background: Transcranial magnetic stimulation (TMS), which is a neuromodulation therapy for psychiatric disorders, is not widely used in Norway. We aimed to investigate whether doctors in mental health care are familiar with and interested in the method, as well as the reasons for its limited use and the key factors required for its implementation.

Material And Method: An anonymous electronic survey questionnaire was distributed to all active members of the Norwegian Psychiatric Association in the autumn of 2022 (n = 1979), consisting of 484 specialty registrars and 1495 specialists.

View Article and Find Full Text PDF

Background: The efficacy of extracorporeal shockwave therapy (ESWT) for treating shoulder calcific tendinitis can be influenced by various prognostic factors. This study aimed to identify prognostic factors associated with the failure of ESWT for symptom relief and to evaluate the predictive capability of the eXtreme Gradient Boosting (XGBoost) algorithm of artificial intelligence techniques in this context.

Methods: This retrospective study enrolled patients with persistent shoulder pain attributed to calcific tendinitis who underwent ESWT after failed conservative treatment between January 1998 and December 2022.

View Article and Find Full Text PDF

Background: An increase in child screen time has been observed throughout the COVID-19 pandemic. Home environment and parenting practices have been associated with child screen time. The purpose of this study was to examine associations between parental use of routines, limit setting, and child screen time during the (COVID-19) pandemic to inform harm-reducing strategies to limit the potential harms ensued by excessive screen use.

View Article and Find Full Text PDF

Significance: Cataract surgery is one of the most performed surgical procedures worldwide. As a potential complication following cataract surgery, dry eye has the potential to impact visual outcomes, lower patient satisfaction, and be detrimental to quality of life.

Purpose: To evaluate the effect of cataract surgery on dry eye outcomes postoperatively.

View Article and Find Full Text PDF

Background: Origami is a popular activity among preschool children and can be used by therapists as an evaluation tool to assess children's development in clinical settings. It is easy to implement, appealing to children, and time-efficient, requiring only simple materials-pieces of paper. Furthermore, the products of origami may reflect children's ages and their visual-motor integration (VMI) development.

View Article and Find Full Text PDF

Background: Baseline lung allograft dysfunction (BLAD) after lung transplant is associated with an increased risk of dying, but the association with health-related quality of life (HRQL) and exercise capacity is not known. We hypothesized that BLAD would be associated with reduced HRQL and 6-min walk distance (6MWD) at 1 y post-lung transplant.

Methods: We analyzed patients who underwent lung transplants in our program from 2004 to 2018 who completed 1-y 36-item Short Form (SF-36) questionnaire and 6MWD testing.

View Article and Find Full Text PDF

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas and the primary cause of mortality in patients with neurofibromatosis type 1 (NF1). These malignancies develop within preexisting benign lesions called plexiform neurofibromas (PNs). PNs are solely driven by biallelic loss eliciting RAS pathway activation, and they respond favorably to MEK inhibitor therapy.

View Article and Find Full Text PDF

Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its highly immunosuppressive microenvironment and the brain immune privilege. Immunotherapy activating the immune system and T lymphocyte infiltration holds great promise against GBM. However, the brain's low immunogenicity and the difficulty of crossing the blood-brain barrier (BBB) hinder therapeutic efficacy.

View Article and Find Full Text PDF

Head and neck squamous cell carcinoma (HNSCC) cells have a high p53 mutation rate, but there were rare reported about the p53 gain of function through the prion-like aggregated form in p53 mutated HNSCC cells. Thioflavin T (ThT) is used to stain prion-like proteins in cells. Previously, we found that ThT and p53 staining were co-localized in HNSCC cells (Detroit 562 cells) with homozygous p53 R175H mutation.

View Article and Find Full Text PDF

Ultrathin indium oxide films show great potential as channel materials of complementary metal oxide semiconductor back-end-of-line transistors due to their high carrier mobility, smooth surface, and low leakage current. However, it has severe thermal stability problems (unstable and negative threshold voltage shifts at high temperatures). In this paper, we clarified how the improved crystallinity of indium oxide by using ultrahigh-temperature rapid thermal O annealing could reduce donor-like defects and suppress thermal-induced defects, drastically enhancing thermal stability.

View Article and Find Full Text PDF

Background/aims: Distal mean nocturnal baseline impedance (MNBI) measuring via pH-impedance may be valuable in diagnosing patients with suspected laryngopharyngeal reflux (LPR). However, its wide adoption is hindered by cost and invasiveness. This study investigates whether baseline impedance measured during high-resolution impedance manometry (HRIM-BI) can predict pathological MNBI.

View Article and Find Full Text PDF

(1) Background: Impeded resolution of inflammation contributes substantially to the pathogenesis of Alzheimer's disease (AD); consequently, resolving inflammation is pivotal to the amelioration of AD pathology. This can potentially be achieved by the treatment with specialized pro-resolving lipid mediators (SPMs), which should resolve neuroinflammation in brains. (2) Methods: Here, we report the histological effects of long-term treatment with an SPM, maresin-like 1 (MarL1), on AD pathogenesis in a transgenic 5xFAD mouse model.

View Article and Find Full Text PDF

Objective: The purpose of this study was to compare the optical, mechanical, and biological properties of two new, inexpensive lithium disilicate (LS2) materials (Lodden (LOD), LD Medical Technology; and BeautyZir (BZ), BeautyZir Technology) to a clinically established LS2 material (IPS e.max CAD (EMAX), Ivoclar Vivadent).

Methods And Materials: The optical properties of the translucency parameter (TP) and opalescence parameter (OP) were obtained with a dental spectrophotometer.

View Article and Find Full Text PDF

Objectives: To evaluate the effectiveness of mini-implant (MI) anchorage versus conventional anchorage for the treatment of skeletal class II malocclusion.

Materials And Methods: The study was conducted on 64 patients with skeletal class II malocclusion. The patients were divided into two groups: 1) 32 patients underwent conventional anchorage, and 2) 32 patients underwent MI anchorage.

View Article and Find Full Text PDF

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

View Article and Find Full Text PDF

Background: Diagnosing laryngopharyngeal reflux (LPR) is challenging due to overlapping symptoms. While proton pump inhibitors (PPIs) are commonly prescribed, reliable predictors of their responsiveness are unclear. Reflux monitoring technologies like dual potential of hydrogen (pH) sensors and multichannel intraluminal impedance-pH (MII-pH) could improve diagnosis.

View Article and Find Full Text PDF
Article Synopsis
  • Aging leads to cellular damage and mitochondrial dysfunction, impacting metabolism and contributing to age-related diseases.
  • The cofactor NAD decreases in tissues with age and is crucial for various metabolic pathways, yet its levels and ratio to NADH remained stable during healthy aging in mice studied.
  • Research showed that older tissues, especially in the brain, increased fatty acid and sphingolipid metabolism, helping to maintain NAD levels, which could be essential for healthy aging.
View Article and Find Full Text PDF

Purpose: Improve the accuracy of one-stage object detection by modifying the YOLOv7 with Convolutional Block Attention Module (CBAM), known as YOLOv7-CBAM, which can automatically identify torn or intact rotator cuff tendon to assist physicians in diagnosing rotator cuff lesions through ultrasound.

Methods: Between 2020 and 2021, patients who experienced shoulder pain for over 3 months and had both ultrasound and MRI examinations were categorized into torn and intact group. To ensure balanced training, we included the same number of patients on both groups.

View Article and Find Full Text PDF

In the past, unsanitary landfills were a common method for municipal solid waste disposal in developing countries. Although many nations have closed these landfills, the environmental pollution risks and impacts persist. This study introduces a new multi-criteria risk assessment framework specifically designed for closed, unsanitary landfills.

View Article and Find Full Text PDF

Objective: Despite certain studies indicating hearing impairments in individuals with polycystic ovary syndrome (PCOS), the correlation between PCOS and sensorineural hearing loss (SNHL) remains inconclusive. This study aimed to investigate the association between PCOS and SNHL.

Data Sources: A systematic literature search was conducted using PubMed, MEDLINE, EMBASE, and the Cochrane Library from inception to June 24, 2024.

View Article and Find Full Text PDF

The prevalence and contributing factors of mental health issues among health workers in Vietnam during the early 2022 Omicron wave remain underexplored. This study investigated the prevalence and factors associated with anxiety and stress among health workers in a Vietnamese hospital during this period. A cross-sectional study, conducted from February 28 to April 14, 2022, at Hanoi Medical University Hospital, assessed anxiety and stress among 754 frontline health workers using the DASS-21 questionnaire via a Google survey.

View Article and Find Full Text PDF