Publications by authors named "Inge Worni-Schudel"
Article Synopsis
- Guidelines suggest brief smoking cessation interventions for hospitalized smokers who are not very motivated to quit, but more intensive interventions might be more effective.
- A study in Switzerland compared outcomes for hospitalized smokers with acute coronary syndrome who received either a proactive intensive smoking cessation intervention or a reactive one, based on their willingness to quit.
- Results showed that after one year, 50% of smokers with low motivation who received the proactive intervention quit smoking, compared to only 19% in the reactive group, indicating that a proactive approach could be beneficial for smokers less motivated to quit.
A subset of autoimmune diseases result from autoantibodies targeting epitopes on matrix collagen. The most extensively studied are anti-glomerular basement membrane glomerulonephritis (or its systemic counterpart Goodpasture's disease) that destroys kidneys and lungs, and rheumatoid arthritis that leads to disabling arthritis. Autoantibodies in these disorders bind evolutionarily conserved conformational epitopes on the noncollagenous domain 1 (NC1) of the alpha3 chain of type IV [alpha3(IV)NC1] collagen in glomerular and alveolar basement membranes, and on native or citrullinated type II collagen (CII) in joint cartilage, respectively.
View Article and Find Full Text PDFBackground: Anti-glomerular basement membrane nephritis and Goodpasture syndrome result from autoantibody (Ab)-mediated destruction of kidney and lung. Ab target the noncollagenous 1 (NC1) domain of alpha3(IV) collagen, but little is known about Ab origins or structure. This ignorance is due in part to the inability to recover monoclonal Ab by transformation of patients' blood cells.
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